Intravenous Glyburide in Medical and Endovascular‐Treated Large‐Core Stroke: A Subgroup Analysis of the CHARM Randomized Clinical Trial - Kimberly, W. Taylor; Saver, Jeffrey L.; Campbell, Bruce C.V.; Albers, Gregory W.; Molyneaux, Bradley J.; Hinson, H.E.; Rocha, Marcelo; Mittal, Shilpi; Bacchi, Stephen; Sharma, Gagan; Cordonnier, Charlotte; Steiner, Thorsten; et al. (Annals of neurology, 2025)
Keywords: Administration, Intravenous; Aged; Cardiovascular system; Cerebral infarction; Clinical trials; Computed tomography; Double-Blind Method; Endovascular Procedures - methods; Female; Glibenclamide; Glyburide - administration & dosage; Glyburide - therapeutic use; Humans; Hypoglycemic Agents - administration & dosage; Independent variables; Infarction; Intravenous administration; Ischemia; Ischemic Stroke - diagnostic imaging; Ischemic Stroke - drug therapy; Magnetic resonance imaging; Male; Middle Aged; Mortality; Patients; Placebos; Stroke; Stroke - diagnostic imaging; Stroke - drug therapy; Stroke volume; Subgroups; t-Plasminogen activator; Thrombectomy; Tissue Plasminogen Activator - therapeutic use; Treatment Outcome