Fetal Cerebrovascular Response to Maternal Hyperoxia Testing and Association With Brain Growth and Postnatal Brain Injury in Congenital Heart Disease

• Published in: Journal of the American Heart Association Vol. 14; no. 15; p. e042014
• Main Authors: Taleb, Mariam, Liu, Jing, Xu, Duan, Zhao, Yii, Moon‐Grady, Anita J., McQuillen, Patrick S., Peyvandi, Shabnam
• Format: Journal Article
• Language: English
• Published: England Wiley 05.08.2025
• Subjects: Adult; Brain - diagnostic imaging; Brain - growth & development; Brain Injuries - diagnostic imaging; Brain Injuries - etiology; Brain Injuries - physiopathology; Cerebrovascular Circulation; congenital heart disease; Female; Gestational Age; Heart Defects, Congenital - complications; Heart Defects, Congenital - diagnostic imaging; Heart Defects, Congenital - physiopathology; Humans; Hyperoxia - complications; Hyperoxia - physiopathology; Infant, Newborn; Magnetic Resonance Imaging; Male; maternal hyperoxia; Middle Cerebral Artery - diagnostic imaging; Middle Cerebral Artery - physiopathology; neurodevelopment; Pregnancy; Prospective Studies; neurodevelopment; congenital heart disease; maternal hyperoxia

Neurodevelopmental outcomes are impaired in significant congenital heart disease (CHD) with prenatal origins. The cerebrovascular response to maternal hyperoxia (MH) varies in fetuses with CHD, which may reflect brain health in utero. We investigated the association between lack of cerebrovascular r...