Inductive and Deductive Approaches to Acute Cell Injury

Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury s...

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Published inInternational scholarly research notices Vol. 2014; pp. 859341 - 15
Main Authors DeGracia, Donald J., Tri Anggraini, Fika, Taha, Doaa Taha Metwally, Huang, Zhi-Feng
Format Journal Article
LanguageEnglish
Published United States Hindawi Publishing Corporation 2014
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Anatomy & physiology
Apoptosis
Biology
Cell death
Cerebral ischemia
Clinical trials
Heart attacks
Injuries
Ischemia
Physics
Review
Science
Studies
Theory
Detroit Michigan
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Abstract Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury system. Here we contrast the application of inductive and deductive models of acute cell injury. Using brain ischemia as a case study, we discuss limitations in inductive inferences, including the inability to unambiguously assign cell death causality and the lack of a systematic quantitative framework. These limitations follow from an overemphasis on qualitative molecular pathways specific to the injured system. Our recently developed nonlinear dynamical theory of cell injury provides a generic, systematic approach to cell injury in which attractor states and system parameters are used to quantitatively characterize acute injury systems. The theoretical, empirical, and therapeutic implications of shifting to a deductive framework are discussed. We illustrate how a deductive mathematical framework offers tangible advantages over qualitative inductive models for the development of therapeutics of acutely injured biological systems.
AbstractList Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury system. Here we contrast the application of inductive and deductive models of acute cell injury. Using brain ischemia as a case study, we discuss limitations in inductive inferences, including the inability to unambiguously assign cell death causality and the lack of a systematic quantitative framework. These limitations follow from an overemphasis on qualitative molecular pathways specific to the injured system. Our recently developed nonlinear dynamical theory of cell injury provides a generic, systematic approach to cell injury in which attractor states and system parameters are used to quantitatively characterize acute injury systems. The theoretical, empirical, and therapeutic implications of shifting to a deductive framework are discussed. We illustrate how a deductive mathematical framework offers tangible advantages over qualitative inductive models for the development of therapeutics of acutely injured biological systems.
Audience Academic
Author Tri Anggraini, Fika
DeGracia, Donald J.
Taha, Doaa Taha Metwally
Huang, Zhi-Feng
AuthorAffiliation 1 Department of Physiology, Wayne State University, 4116 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
2 Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201, USA
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  surname: DeGracia
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  givenname: Fika
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  fullname: Tri Anggraini, Fika
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  givenname: Doaa Taha Metwally
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  givenname: Zhi-Feng
  surname: Huang
  fullname: Huang, Zhi-Feng
  organization: Department of Physics and Astronomy Wayne State University Detroit MI 48201 USA wayne.edu
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ContentType Journal Article
Copyright Copyright © 2014 Donald J. DeGracia et al.
COPYRIGHT 2014 John Wiley & Sons, Inc.
Copyright © 2014 Donald J. DeGracia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2014 Donald J. DeGracia et al. 2014
Copyright_xml – notice: Copyright © 2014 Donald J. DeGracia et al.
– notice: COPYRIGHT 2014 John Wiley & Sons, Inc.
– notice: Copyright © 2014 Donald J. DeGracia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2014 Donald J. DeGracia et al. 2014
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44
88
45
89
46
(16) 1962; 1
47
48
49
(9) 1964
90
91
92
93
50
94
51
95
53
10
54
11
55
12
56
57
14
58
15
59
18
19
(64) 2003; 23
(76) 2007; 18
1
2
3
5
6
7
8
60
61
62
63
20
21
66
67
68
25
69
26
27
(65) 2002; 22
28
(13) 2008; 10
70
71
72
73
30
74
31
75
32
33
77
78
79
36
37
38
(85) 2013; 3
80
81
82
83
40
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41
42
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43
87
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Snippet Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell...
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SubjectTerms Anatomy & physiology
Apoptosis
Biology
Cell death
Cerebral ischemia
Clinical trials
Heart attacks
Injuries
Ischemia
Physics
Review
Science
Studies
Theory
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Title Inductive and Deductive Approaches to Acute Cell Injury
URI https://dx.doi.org/10.1155/2014/859341
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Volume 2014
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