Sickle cell syndromes. I. Hemoglobin SC-alpha-thalassemia

• Published in: Pediatric research Vol. 10; no. 6; pp. 613 - 620
• Main Authors: Honig, G R, Gunay, U, Mason, R G, Vida, L N, Ferenc, C
• Format: Journal Article
• Language: English
• Published: United States 01.06.1976
• Subjects: Anemia, Sickle Cell - blood; Anemia, Sickle Cell - genetics; Child; Erythrocytes - metabolism; Female; Globins - biosynthesis; Hemoglobin C - analysis; Hemoglobin C Disease - blood; Hemoglobin C Disease - genetics; Hemoglobin, Sickle - analysis; Humans; Osmotic Fragility; Pedigree; Sickle Cell Trait - blood; Sickle Cell Trait - genetics; Thalassemia - blood; Thalassemia - genetics

Hematologic and globin synthesis studies were performed in a black American family in which the genes for alpha-thalassemia and hemoglobins (Hb) S and C were segregating. The following distribution of these abnormalities was found: father, sickle cell trait + alpha-thalassemia; mother, HbC trait + a...