Impairment of Vα24-Jα18+Vβ11+ natural killer T cells in adult acute lymphoblastic leukemia patients

• Published in: Experimental cell research Vol. 374; no. 1; pp. 69 - 75
• Main Authors: Zhao, Haijun, Li, Zhifeng, Xie, Shiting, Luo, Yiming, Zhou, Yong, Deng, Manman, Zeng, Hanyan, Zhao, Jintao, Yu, Lian, Xu, Bing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Acute lymphoblastic leukemia; Adult; Aged; B-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Female; Humans; IL-21; Interleukins - blood; Lymphocyte Count; Male; Middle Aged; Natural killer T cells; Natural Killer T-Cells - immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Receptors, Antigen, T-Cell, alpha-beta - metabolism; Receptors, Interleukin-21 - metabolism; Acute lymphoblastic leukemia; Natural killer T cells; IL-21

Type I natural killer T (NKT) cells are attractive candidates for cancer immunotherapy. In this study, we examined the characteristics of type I NKT cells in patients with adult B-cell acute lymphoblastic leukemia (ALL). We first identified type I NKT cells as Vα24-Jα18 and Vβ11 double-positive CD3+...