A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica - and Ascophyllum nodosum -derived fucoidans in apolipoprotein E-deficient mice
The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that - and -derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of act...
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Published in | Food & function Vol. 15; no. 11; pp. 5955 - 5971 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
04.06.2024
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Subjects | |
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Abstract | The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that
- and
-derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action. Chemical analysis demonstrated that the percentage contents of sulfate, glucuronic acid, and galactose were higher in
-derived fucoidans than those of
-derived fucoidans. In hyperlipidemic apolipoprotein E-deficient mice, both
- and
-derived fucoidans significantly decreased the plasma and hepatic levels of total cholesterol and triglyceride, leading to the reduction of atherosclerotic plaques. Western blotting experiments demonstrated that these fucoidans significantly enhanced the expression and levels of scavenger receptor B type 1, cholesterol 7 alpha-hydroxylase A1, and peroxisome proliferator-activated receptor (PPAR)-α, contributing to circulating lipoprotein clearance and fatty acid degradation, respectively. Differentially,
-derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases. |
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AbstractList | The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that
- and
-derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action. Chemical analysis demonstrated that the percentage contents of sulfate, glucuronic acid, and galactose were higher in
-derived fucoidans than those of
-derived fucoidans. In hyperlipidemic apolipoprotein E-deficient mice, both
- and
-derived fucoidans significantly decreased the plasma and hepatic levels of total cholesterol and triglyceride, leading to the reduction of atherosclerotic plaques. Western blotting experiments demonstrated that these fucoidans significantly enhanced the expression and levels of scavenger receptor B type 1, cholesterol 7 alpha-hydroxylase A1, and peroxisome proliferator-activated receptor (PPAR)-α, contributing to circulating lipoprotein clearance and fatty acid degradation, respectively. Differentially,
-derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases. The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that Laminaria japonica - and Ascophyllum nodosum -derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action. Chemical analysis demonstrated that the percentage contents of sulfate, glucuronic acid, and galactose were higher in L. japonica -derived fucoidans than those of A. nodosum -derived fucoidans. In hyperlipidemic apolipoprotein E-deficient mice, both A. nodosum - and L. japonica -derived fucoidans significantly decreased the plasma and hepatic levels of total cholesterol and triglyceride, leading to the reduction of atherosclerotic plaques. Western blotting experiments demonstrated that these fucoidans significantly enhanced the expression and levels of scavenger receptor B type 1, cholesterol 7 alpha-hydroxylase A1, and peroxisome proliferator-activated receptor (PPAR)-α, contributing to circulating lipoprotein clearance and fatty acid degradation, respectively. Differentially, L. japonica -derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases. The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that Laminaria japonica- and Ascophyllum nodosum-derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action. Chemical analysis demonstrated that the percentage contents of sulfate, glucuronic acid, and galactose were higher in L. japonica-derived fucoidans than those of A. nodosum-derived fucoidans. In hyperlipidemic apolipoprotein E-deficient mice, both A. nodosum- and L. japonica-derived fucoidans significantly decreased the plasma and hepatic levels of total cholesterol and triglyceride, leading to the reduction of atherosclerotic plaques. Western blotting experiments demonstrated that these fucoidans significantly enhanced the expression and levels of scavenger receptor B type 1, cholesterol 7 alpha-hydroxylase A1, and peroxisome proliferator-activated receptor (PPAR)-α, contributing to circulating lipoprotein clearance and fatty acid degradation, respectively. Differentially, L. japonica-derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases.The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that Laminaria japonica- and Ascophyllum nodosum-derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action. Chemical analysis demonstrated that the percentage contents of sulfate, glucuronic acid, and galactose were higher in L. japonica-derived fucoidans than those of A. nodosum-derived fucoidans. In hyperlipidemic apolipoprotein E-deficient mice, both A. nodosum- and L. japonica-derived fucoidans significantly decreased the plasma and hepatic levels of total cholesterol and triglyceride, leading to the reduction of atherosclerotic plaques. Western blotting experiments demonstrated that these fucoidans significantly enhanced the expression and levels of scavenger receptor B type 1, cholesterol 7 alpha-hydroxylase A1, and peroxisome proliferator-activated receptor (PPAR)-α, contributing to circulating lipoprotein clearance and fatty acid degradation, respectively. Differentially, L. japonica-derived fucoidan significantly increased the LXR/ATP-binding cassette G8 signaling pathway in the small intestine, as revealed by real-time quantitative PCR, which may lead to further cholesterol and other lipid excretion. Collectively, these data are useful for understanding the hypolipidemic mechanisms of action of seaweed-derived fucoidans, and their potential application for the prevention and/or treatment of atherosclerotic cardiovascular diseases. |
Author | Wang, Xue Sui, Feng-Rong Liu, Hai-Di Ma, Dong-Yue Wang, Yan-Ming Zhang, Xue-Ying Guo, Shou-Dong Liu, Tian Liu, Xiao-Xiao |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38738998$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.3390/ijms19040949 10.1016/j.jmb.2022.167795 10.3109/13880200903150435 10.1039/C3FO60716J 10.1016/j.biochi.2005.08.010 10.1021/acs.jafc.7b04033 10.1016/j.ijbiomac.2015.11.036 10.1016/j.ijbiomac.2017.07.148 10.1016/j.atherosclerosis.2016.03.016 10.1016/j.carbpol.2018.10.097 10.1016/j.ijbiomac.2023.125008 10.1016/j.bbrc.2023.01.091 10.1021/acs.jafc.9b00970 10.1016/j.jff.2018.10.013 10.1016/j.ijbiomac.2010.05.010 10.1093/glycob/cwm014 10.2174/1573403X14666180123165542 10.1161/ATVBAHA.109.191197 10.1016/j.jphs.2016.03.007 10.1039/D2FO00480A 10.1016/j.ijbiomac.2021.02.191 10.3390/md16040132 10.1080/17425255.2018.1483337 10.3389/fcvm.2018.00153 10.4103/0976-500X.119726 10.1177/20406223221076891 10.1016/j.ijbiomac.2019.08.002 10.1016/S0008-6215(00)00314-1 10.1016/0003-2697(62)90095-7 10.3389/fmolb.2022.909151 10.1016/j.plipres.2018.12.002 10.2146/ajhp120131 10.1371/journal.pone.0101269 10.1016/j.jnutbio.2016.01.011 10.3390/md18090485 10.1007/s11418-006-0046-2 10.1074/jbc.M310892200 10.1089/jmf.2013.0053 10.3389/fphar.2022.1000315 10.1161/ATVBAHA.114.305116 10.1016/j.atherosclerosis.2018.11.013 10.1039/C8FO01174E 10.3389/fnut.2022.971581 10.1016/j.fct.2010.05.063 10.1017/S000711451100256X 10.1039/C6FO00309E 10.1161/CIRCRESAHA.118.312782 10.1039/C9FO00619B 10.1016/j.carbpol.2021.118247 10.1016/j.carbpol.2024.121884 10.1016/j.carbpol.2017.05.063 10.1016/S0021-9150(01)00678-5 10.1016/j.ejphar.2009.02.024 10.1016/j.ijbiomac.2018.06.054 10.1080/14786419.2014.948436 10.3390/nu10060686 10.1021/acs.jafc.9b01321 10.1021/ac60111a017 10.1016/j.jep.2016.06.054 10.1016/j.ejmech.2017.09.020 10.1016/j.ijbiomac.2019.05.070 10.1016/j.ijbiomac.2022.02.189 10.3389/fmolb.2023.1147699 10.1016/j.foodchem.2021.129908 10.1097/FJC.0b013e31816a5be3 10.1124/mol.113.085100 10.1016/j.ijbiomac.2022.08.059 10.14218/JCTH.2017.00061 10.1016/0003-2697(71)90167-9 10.1039/C8FO02375A |
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References | Peters (D3FO05521C/cit1/1) 2016; 248 Luijten (D3FO05521C/cit2/1) 2019; 280 Wang (D3FO05521C/cit69/1) 2010; 47 Xu (D3FO05521C/cit17/1) 2019; 206 Wang (D3FO05521C/cit40/1) 2023; 254 Shang (D3FO05521C/cit71/1) 2016; 7 Zhao (D3FO05521C/cit32/1) 2021; 268 Yang (D3FO05521C/cit15/1) 2019; 67 Wang (D3FO05521C/cit7/1) 2022; 13 Liang (D3FO05521C/cit53/1) 2016; 191 Yang (D3FO05521C/cit11/1) 2019; 134 Ward (D3FO05521C/cit9/1) 2019; 124 Chen (D3FO05521C/cit68/1) 2017; 105 Shan (D3FO05521C/cit39/1) 2016; 82 Hedrington (D3FO05521C/cit10/1) 2018; 14 Xu (D3FO05521C/cit42/1) 2014; 5 Cheng (D3FO05521C/cit31/1) 2020; 2020 Liu (D3FO05521C/cit72/1) 2021; 358 Yu (D3FO05521C/cit24/1) 2019; 73 Rygiel (D3FO05521C/cit4/1) 2018; 14 Darimont (D3FO05521C/cit62/1) 2006; 88 Hernández-Corona (D3FO05521C/cit50/1) 2014; 17 Dubois (D3FO05521C/cit25/1) 1956; 28 Charan (D3FO05521C/cit30/1) 2013; 4 Zhang (D3FO05521C/cit59/1) 2022; 9 Park (D3FO05521C/cit56/1) 2016; 131 Yang (D3FO05521C/cit49/1) 2023; 10 Fu (D3FO05521C/cit48/1) 2003; 278 Do (D3FO05521C/cit55/1) 2011; 106 Singh (D3FO05521C/cit5/1) 2017; 140 Sudirman (D3FO05521C/cit33/1) 2018; 10 Wu (D3FO05521C/cit57/1) 2019; 10 Huang (D3FO05521C/cit13/1) 2010; 48 Patil (D3FO05521C/cit18/1) 2018; 5 Sun (D3FO05521C/cit44/1) 2022; 220 Calkin (D3FO05521C/cit64/1) 2010; 30 Shan (D3FO05521C/cit23/1) 2020; 18 Li (D3FO05521C/cit41/1) 2018; 9 Yokota (D3FO05521C/cit16/1) 2016; 32 Pozharitskaya (D3FO05521C/cit65/1) 2018; 16 Cuong (D3FO05521C/cit14/1) 2015; 29 Miao (D3FO05521C/cit3/1) 2023; 242 Dai (D3FO05521C/cit46/1) 2008; 51 Zheng (D3FO05521C/cit60/1) 2014; 9 Kalita (D3FO05521C/cit19/1) 2022; 206 Ren (D3FO05521C/cit36/1) 2019; 140 Zhang (D3FO05521C/cit52/1) 2022; 13 Peng (D3FO05521C/cit35/1) 2018; 51 Fernandes-Braga (D3FO05521C/cit37/1) 2023; 650 Moslehi (D3FO05521C/cit61/1) 2018; 6 Wang (D3FO05521C/cit34/1) 2002; 162 Yin (D3FO05521C/cit28/1) 2019; 10 Xu (D3FO05521C/cit43/1) 2018; 118 Farhat (D3FO05521C/cit66/1) 2022; 434 Ozawa (D3FO05521C/cit38/1) 2006; 60 Attridge (D3FO05521C/cit8/1) 2013; 70 Lin (D3FO05521C/cit12/1) 2022; 13 Shi (D3FO05521C/cit22/1) 2024; 332 Cumashi (D3FO05521C/cit20/1) 2007; 17 Terho (D3FO05521C/cit26/1) 1971; 41 Gao (D3FO05521C/cit70/1) 2019; 67 Li (D3FO05521C/cit51/1) 2017; 173 Zhang (D3FO05521C/cit6/1) 2022; 9 Srivastava (D3FO05521C/cit63/1) 2009; 607 Wang (D3FO05521C/cit29/1) 2021; 179 Kwon (D3FO05521C/cit45/1) 2010; 48 Chen (D3FO05521C/cit47/1) 2015; 35 Bitter (D3FO05521C/cit27/1) 1962; 4 Gao (D3FO05521C/cit67/1) 2017; 65 Jeong (D3FO05521C/cit54/1) 2013; 84 Lamichane (D3FO05521C/cit58/1) 2018; 19 Chevolot (D3FO05521C/cit21/1) 2001; 330 |
References_xml | – volume: 19 start-page: 949 issue: 4 year: 2018 ident: D3FO05521C/cit58/1 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms19040949 contributor: fullname: Lamichane – volume: 434 start-page: 167795 issue: 20 year: 2022 ident: D3FO05521C/cit66/1 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2022.167795 contributor: fullname: Farhat – volume: 48 start-page: 422 issue: 4 year: 2010 ident: D3FO05521C/cit13/1 publication-title: Pharm. Biol. doi: 10.3109/13880200903150435 contributor: fullname: Huang – volume: 5 start-page: 1547 issue: 7 year: 2014 ident: D3FO05521C/cit42/1 publication-title: Food Funct. doi: 10.1039/C3FO60716J contributor: fullname: Xu – volume: 88 start-page: 309 issue: 3–4 year: 2006 ident: D3FO05521C/cit62/1 publication-title: Biochimie doi: 10.1016/j.biochi.2005.08.010 contributor: fullname: Darimont – volume: 65 start-page: 9790 issue: 44 year: 2017 ident: D3FO05521C/cit67/1 publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.7b04033 contributor: fullname: Gao – volume: 82 start-page: 249 year: 2016 ident: D3FO05521C/cit39/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2015.11.036 contributor: fullname: Shan – volume: 105 start-page: 1421 issue: Pt 2 year: 2017 ident: D3FO05521C/cit68/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.07.148 contributor: fullname: Chen – volume: 248 start-page: 123 year: 2016 ident: D3FO05521C/cit1/1 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2016.03.016 contributor: fullname: Peters – volume: 206 start-page: 110 year: 2019 ident: D3FO05521C/cit17/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2018.10.097 contributor: fullname: Xu – volume: 242 start-page: 125008 issue: Pt 2 year: 2023 ident: D3FO05521C/cit3/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2023.125008 contributor: fullname: Miao – volume: 650 start-page: 21 year: 2023 ident: D3FO05521C/cit37/1 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2023.01.091 contributor: fullname: Fernandes-Braga – volume: 67 start-page: 7496 issue: 26 year: 2019 ident: D3FO05521C/cit70/1 publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.9b00970 contributor: fullname: Gao – volume: 51 start-page: 8 year: 2018 ident: D3FO05521C/cit35/1 publication-title: J. Funct. Foods doi: 10.1016/j.jff.2018.10.013 contributor: fullname: Peng – volume: 47 start-page: 126 issue: 2 year: 2010 ident: D3FO05521C/cit69/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2010.05.010 contributor: fullname: Wang – volume: 17 start-page: 541 issue: 5 year: 2007 ident: D3FO05521C/cit20/1 publication-title: Glycobiology doi: 10.1093/glycob/cwm014 contributor: fullname: Cumashi – volume: 14 start-page: 67 issue: 1 year: 2018 ident: D3FO05521C/cit4/1 publication-title: Curr. Cardiol. Rev. doi: 10.2174/1573403X14666180123165542 contributor: fullname: Rygiel – volume: 254 start-page: 127955 issue: Pt 2 year: 2023 ident: D3FO05521C/cit40/1 publication-title: Int. J. Biol. Macromol. contributor: fullname: Wang – volume: 30 start-page: 1513 issue: 8 year: 2010 ident: D3FO05521C/cit64/1 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.109.191197 contributor: fullname: Calkin – volume: 131 start-page: 84 issue: 2 year: 2016 ident: D3FO05521C/cit56/1 publication-title: J. Pharmacol. Sci. doi: 10.1016/j.jphs.2016.03.007 contributor: fullname: Park – volume: 13 start-page: 6259 issue: 11 year: 2022 ident: D3FO05521C/cit52/1 publication-title: Food Funct. doi: 10.1039/D2FO00480A contributor: fullname: Zhang – volume: 179 start-page: 407 year: 2021 ident: D3FO05521C/cit29/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2021.02.191 contributor: fullname: Wang – volume: 16 start-page: 132 issue: 4 year: 2018 ident: D3FO05521C/cit65/1 publication-title: Mar. Drugs doi: 10.3390/md16040132 contributor: fullname: Pozharitskaya – volume: 14 start-page: 671 issue: 7 year: 2018 ident: D3FO05521C/cit10/1 publication-title: Expert Opin. Drug Metab. Toxicol. doi: 10.1080/17425255.2018.1483337 contributor: fullname: Hedrington – volume: 5 start-page: 153 year: 2018 ident: D3FO05521C/cit18/1 publication-title: Front. Cardiovasc. Med. doi: 10.3389/fcvm.2018.00153 contributor: fullname: Patil – volume: 4 start-page: 303 year: 2013 ident: D3FO05521C/cit30/1 publication-title: J. Pharmacol. Pharmacother. doi: 10.4103/0976-500X.119726 contributor: fullname: Charan – volume: 13 start-page: 20406223221076891 year: 2022 ident: D3FO05521C/cit7/1 publication-title: Ther. Adv. Chronic Dis. doi: 10.1177/20406223221076891 contributor: fullname: Wang – volume: 140 start-page: 188 year: 2019 ident: D3FO05521C/cit36/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2019.08.002 contributor: fullname: Ren – volume: 330 start-page: 529 issue: 4 year: 2001 ident: D3FO05521C/cit21/1 publication-title: Carbohydr. Res. doi: 10.1016/S0008-6215(00)00314-1 contributor: fullname: Chevolot – volume: 4 start-page: 330 year: 1962 ident: D3FO05521C/cit27/1 publication-title: Anal. Biochem. doi: 10.1016/0003-2697(62)90095-7 contributor: fullname: Bitter – volume: 9 start-page: 909151 year: 2022 ident: D3FO05521C/cit6/1 publication-title: Front. Mol. Biosci. doi: 10.3389/fmolb.2022.909151 contributor: fullname: Zhang – volume: 73 start-page: 65 year: 2019 ident: D3FO05521C/cit24/1 publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2018.12.002 contributor: fullname: Yu – volume: 70 start-page: 1219 issue: 14 year: 2013 ident: D3FO05521C/cit8/1 publication-title: Am. J. Health-Syst. Pharm. doi: 10.2146/ajhp120131 contributor: fullname: Attridge – volume: 9 start-page: e101269 issue: 6 year: 2014 ident: D3FO05521C/cit60/1 publication-title: PLoS One doi: 10.1371/journal.pone.0101269 contributor: fullname: Zheng – volume: 32 start-page: 46 year: 2016 ident: D3FO05521C/cit16/1 publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2016.01.011 contributor: fullname: Yokota – volume: 18 start-page: 485 issue: 9 year: 2020 ident: D3FO05521C/cit23/1 publication-title: Mar. Drugs doi: 10.3390/md18090485 contributor: fullname: Shan – volume: 60 start-page: 236 issue: 3 year: 2006 ident: D3FO05521C/cit38/1 publication-title: J. Nat. Med. doi: 10.1007/s11418-006-0046-2 contributor: fullname: Ozawa – volume: 278 start-page: 52559 issue: 52 year: 2003 ident: D3FO05521C/cit48/1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M310892200 contributor: fullname: Fu – volume: 17 start-page: 830 issue: 7 year: 2014 ident: D3FO05521C/cit50/1 publication-title: J. Med. Food doi: 10.1089/jmf.2013.0053 contributor: fullname: Hernández-Corona – volume: 13 start-page: 1000315 year: 2022 ident: D3FO05521C/cit12/1 publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.1000315 contributor: fullname: Lin – volume: 35 start-page: 948 issue: 4 year: 2015 ident: D3FO05521C/cit47/1 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.114.305116 contributor: fullname: Chen – volume: 280 start-page: 1 year: 2019 ident: D3FO05521C/cit2/1 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2018.11.013 contributor: fullname: Luijten – volume: 9 start-page: 5371 year: 2018 ident: D3FO05521C/cit41/1 publication-title: Food Funct. doi: 10.1039/C8FO01174E contributor: fullname: Li – volume: 9 start-page: 971581 year: 2022 ident: D3FO05521C/cit59/1 publication-title: Front. Nutr. doi: 10.3389/fnut.2022.971581 contributor: fullname: Zhang – volume: 48 start-page: 2298 year: 2010 ident: D3FO05521C/cit45/1 publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2010.05.063 contributor: fullname: Kwon – volume: 106 start-page: 1855 issue: 12 year: 2011 ident: D3FO05521C/cit55/1 publication-title: Br. J. Nutr. doi: 10.1017/S000711451100256X contributor: fullname: Do – volume: 7 start-page: 3224 issue: 7 year: 2016 ident: D3FO05521C/cit71/1 publication-title: Food Funct. doi: 10.1039/C6FO00309E contributor: fullname: Shang – volume: 124 start-page: 328 issue: 2 year: 2019 ident: D3FO05521C/cit9/1 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.118.312782 contributor: fullname: Ward – volume: 10 start-page: 5124 issue: 8 year: 2019 ident: D3FO05521C/cit28/1 publication-title: Food Funct. doi: 10.1039/C9FO00619B contributor: fullname: Yin – volume: 268 start-page: 118247 year: 2021 ident: D3FO05521C/cit32/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2021.118247 contributor: fullname: Zhao – volume: 332 start-page: 121884 year: 2024 ident: D3FO05521C/cit22/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2024.121884 contributor: fullname: Shi – volume: 173 start-page: 330 year: 2017 ident: D3FO05521C/cit51/1 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2017.05.063 contributor: fullname: Li – volume: 162 start-page: 23 issue: 1 year: 2002 ident: D3FO05521C/cit34/1 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(01)00678-5 contributor: fullname: Wang – volume: 607 start-page: 258 issue: 1–3 year: 2009 ident: D3FO05521C/cit63/1 publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2009.02.024 contributor: fullname: Srivastava – volume: 118 start-page: 365 issue: Pt A year: 2018 ident: D3FO05521C/cit43/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2018.06.054 contributor: fullname: Xu – volume: 29 start-page: 411 issue: 5 year: 2015 ident: D3FO05521C/cit14/1 publication-title: Nat. Prod. Res. doi: 10.1080/14786419.2014.948436 contributor: fullname: Cuong – volume: 10 start-page: 686 issue: 6 year: 2018 ident: D3FO05521C/cit33/1 publication-title: Nutrients doi: 10.3390/nu10060686 contributor: fullname: Sudirman – volume: 2020 start-page: 3186306 year: 2020 ident: D3FO05521C/cit31/1 publication-title: Oxid. Med. Cell. Longevity contributor: fullname: Cheng – volume: 67 start-page: 5782 issue: 20 year: 2019 ident: D3FO05521C/cit15/1 publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.9b01321 contributor: fullname: Yang – volume: 28 start-page: 350 issue: 3 year: 1956 ident: D3FO05521C/cit25/1 publication-title: Anal. Chem. doi: 10.1021/ac60111a017 contributor: fullname: Dubois – volume: 191 start-page: 341 year: 2016 ident: D3FO05521C/cit53/1 publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.06.054 contributor: fullname: Liang – volume: 140 start-page: 331 year: 2017 ident: D3FO05521C/cit5/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2017.09.020 contributor: fullname: Singh – volume: 134 start-page: 759 year: 2019 ident: D3FO05521C/cit11/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2019.05.070 contributor: fullname: Yang – volume: 206 start-page: 681 year: 2022 ident: D3FO05521C/cit19/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.02.189 contributor: fullname: Kalita – volume: 10 start-page: 1147699 year: 2023 ident: D3FO05521C/cit49/1 publication-title: Front. Mol. Biosci. doi: 10.3389/fmolb.2023.1147699 contributor: fullname: Yang – volume: 358 start-page: 129908 year: 2021 ident: D3FO05521C/cit72/1 publication-title: Food Chem. doi: 10.1016/j.foodchem.2021.129908 contributor: fullname: Liu – volume: 51 start-page: 467 issue: 5 year: 2008 ident: D3FO05521C/cit46/1 publication-title: J. Cardiovasc. Pharmacol. doi: 10.1097/FJC.0b013e31816a5be3 contributor: fullname: Dai – volume: 84 start-page: 147 issue: 1 year: 2013 ident: D3FO05521C/cit54/1 publication-title: Mol. Pharmacol. doi: 10.1124/mol.113.085100 contributor: fullname: Jeong – volume: 220 start-page: 371 year: 2022 ident: D3FO05521C/cit44/1 publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.08.059 contributor: fullname: Sun – volume: 6 start-page: 332 issue: 3 year: 2018 ident: D3FO05521C/cit61/1 publication-title: J. Clin. Transl. Hepatol. doi: 10.14218/JCTH.2017.00061 contributor: fullname: Moslehi – volume: 41 start-page: 471 issue: 2 year: 1971 ident: D3FO05521C/cit26/1 publication-title: Anal. Biochem. doi: 10.1016/0003-2697(71)90167-9 contributor: fullname: Terho – volume: 10 start-page: 2330 issue: 5 year: 2019 ident: D3FO05521C/cit57/1 publication-title: Food Funct. doi: 10.1039/C8FO02375A contributor: fullname: Wu |
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-derived fucoidans have type... The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that Laminaria japonica - and... The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that Laminaria japonica- and Ascophyllum... |
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SubjectTerms | Algae Apolipoprotein E Apolipoproteins Arteriosclerosis Ascophyllum nodosum Atherosclerosis Cardiovascular diseases Chemical analysis Cholesterol Comparative studies Fucoidan Galactose Intestine Laminaria japonica Lipids Peroxisome proliferator-activated receptors Receptors Scavenger receptors Seaweeds Signal transduction Small intestine Species diversity Triglycerides Western blotting |
Title | A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica - and Ascophyllum nodosum -derived fucoidans in apolipoprotein E-deficient mice |
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