Efficacy of recombinant human granulocyte-colony stimulating factor alone and in combination with antifungal agents against disseminated trichosporonosis in neutropenic mice

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 2; no. 4; pp. 232 - 239
• Main Authors: Perparim, Kamberi, Hashimoto, Atsuro, Nasu, Masaru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 1996
• Subjects: antifungal agents; neutropenic mice; rhG-CSF; trichosporonosis; neutropenic mice; antifungal agents; trichosporonosis; rhG-CSF

The ability of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to protect and potentiate the activity of antifungal agents against a lethal Trichosporon beigelii infection in myelosuppressed mice was evaluated in this study. Mice were rendered neutropenic by 2 consecutive-day intra...