Synthesis of novel 3-amino-5-trifluoromethylazoles: A convenient method of obtaining N-(azol-3-yl)amines

• Published in: Synthesis (Stuttgart) no. 9; pp. 1485 - 1493
• Main Authors: Martins, MAP, Cunico, W, Brondani, S, Peres, RL, Zimmermann, N, Rosa, FA, Fiss, GF, Zanatta, N, Bonacorso, HG
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 03.05.2006
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; azolylation; ETHERS; ACID; amines; isoxazoles; pyrazoles; enones

A convenient method to obtain 10 3-amino-5-trifluoromethyl-5-hydroxy-4,5-dihydroisoxazoles and 18 3-amino-5-trifluoromethyl-1H-pyrazoles by cyclocondensation reaction of 4-amino4-etlioxy-1,1,1,-trifluorobut-3-en-2-ones [CF3COCH=C(OEt)NHR, where R=H, Me, Et, CH2CH2OH, CMe2Et, CH2Ph, Ph, 4-NH2C6H4, 4-...