Synthesis of novel 3-amino-5-trifluoromethylazoles: A convenient method of obtaining N-(azol-3-yl)amines
A convenient method to obtain 10 3-amino-5-trifluoromethyl-5-hydroxy-4,5-dihydroisoxazoles and 18 3-amino-5-trifluoromethyl-1H-pyrazoles by cyclocondensation reaction of 4-amino4-etlioxy-1,1,1,-trifluorobut-3-en-2-ones [CF3COCH=C(OEt)NHR, where R=H, Me, Et, CH2CH2OH, CMe2Et, CH2Ph, Ph, 4-NH2C6H4, 4-...
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Published in | Synthesis (Stuttgart) no. 9; pp. 1485 - 1493 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
STUTTGART
Thieme Medical Publishers
03.05.2006
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Subjects | |
Online Access | Get more information |
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Summary: | A convenient method to obtain 10 3-amino-5-trifluoromethyl-5-hydroxy-4,5-dihydroisoxazoles and 18 3-amino-5-trifluoromethyl-1H-pyrazoles by cyclocondensation reaction of 4-amino4-etlioxy-1,1,1,-trifluorobut-3-en-2-ones [CF3COCH=C(OEt)NHR, where R=H, Me, Et, CH2CH2OH, CMe2Et, CH2Ph, Ph, 4-NH2C6H4, 4-AcC6H4, 4-NO2C6H4, 5-methylisoxazol-3-yl, thiazol-2-yl, CH2CO2Et, CH(Ph)CO2Me, CH(i-BU)CO2Et] with hydroxylamine, hydrazine and phenylhydrazine is reported. |
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ISSN: | 0039-7881 1437-210X |
DOI: | 10.1055/s-2006-926443 |