An Overview of Therapy Guidelines for Cardiac Arrest and the Potential Benefits of Hemoglobin-Based Oxygen Carriers

Currently, there is an unmet therapeutic need for the medical management of cardiac arrest, as is evident from the high mortality rate associated with this condition. These dire outcomes can be attributed to the severe nature and poor prognosis of this disorder. However, the current treatment modali...

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Published inCardiogenetics Vol. 12; no. 1; pp. 37 - 48
Main Authors Wollocko, Brian M., Papian-Gorji, Bardia, Yen, Winston, Zahid, Urooj, Shah, Nilank, Steier, Kenneth, Wollocko, Hanna
Format Journal Article
LanguageEnglish
Published Caserta MDPI AG 01.01.2022
Subjects
Cardiac arrest
cardiac resuscitation
Cardiopulmonary resuscitation
Cardiovascular disease
CPR
Cytokines
Defibrillators
Hemoglobin
hemoglobin-based oxygen carriers (HBOCs)
Hospitals
Ischemia
Metabolism
Mortality
oxygen delivery
Pathology
Pathophysiology
Sepsis
tissue reperfusion
United States > US
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Abstract Currently, there is an unmet therapeutic need for the medical management of cardiac arrest, as is evident from the high mortality rate associated with this condition. These dire outcomes can be attributed to the severe nature and poor prognosis of this disorder. However, the current treatment modalities, while helping to augment survival, are limited and do not offer adequate improvements to outcomes. Treatment modalities are particularly lacking when considering the underlying pathophysiology of the metabolic phase of cardiac arrest. In this study, we explore the three phases of cardiac arrest and assess the factors related to positive clinical outcomes and survival for these events. Furthermore, we evaluate the present guidelines for resuscitation and recovery, the issues related to ischemia and tissue reperfusion, and the benefit of oxygen-delivery therapeutic methods including blood transfusion therapy and synthetic hemoglobins (HBOCs). The current therapy protocols are limited specifically by the lack of an efficient method of oxygen delivery to address the metabolic phase of cardiac arrest. In this article, we investigate the next generation of HBOCs and review their properties that make them attractive for their potential application in the treatment of cardiac arrest. These products may be a viable solution to address complications associated with ischemia, reperfusion injury, and organ damage.
AbstractList Currently, there is an unmet therapeutic need for the medical management of cardiac arrest, as is evident from the high mortality rate associated with this condition. These dire outcomes can be attributed to the severe nature and poor prognosis of this disorder. However, the current treatment modalities, while helping to augment survival, are limited and do not offer adequate improvements to outcomes. Treatment modalities are particularly lacking when considering the underlying pathophysiology of the metabolic phase of cardiac arrest. In this study, we explore the three phases of cardiac arrest and assess the factors related to positive clinical outcomes and survival for these events. Furthermore, we evaluate the present guidelines for resuscitation and recovery, the issues related to ischemia and tissue reperfusion, and the benefit of oxygen-delivery therapeutic methods including blood transfusion therapy and synthetic hemoglobins (HBOCs). The current therapy protocols are limited specifically by the lack of an efficient method of oxygen delivery to address the metabolic phase of cardiac arrest. In this article, we investigate the next generation of HBOCs and review their properties that make them attractive for their potential application in the treatment of cardiac arrest. These products may be a viable solution to address complications associated with ischemia, reperfusion injury, and organ damage.
Author Papian-Gorji, Bardia
Wollocko, Brian M.
Zahid, Urooj
Yen, Winston
Wollocko, Hanna
Shah, Nilank
Steier, Kenneth
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Snippet Currently, there is an unmet therapeutic need for the medical management of cardiac arrest, as is evident from the high mortality rate associated with this...
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StartPage 37
SubjectTerms Cardiac arrest
cardiac resuscitation
Cardiopulmonary resuscitation
Cardiovascular disease
CPR
Cytokines
Defibrillators
Hemoglobin
hemoglobin-based oxygen carriers (HBOCs)
Hospitals
Ischemia
Metabolism
Mortality
oxygen delivery
Pathology
Pathophysiology
Sepsis
tissue reperfusion
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Title An Overview of Therapy Guidelines for Cardiac Arrest and the Potential Benefits of Hemoglobin-Based Oxygen Carriers
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