Phase I Clinical Studies of S-1090: Safety and Pharmacokinetics
S-1090, an oral cephem antibiotic, was given to healthy male volunteers in single (10 to 400mg) and multiple (200mg, twice a day) doses. There were no abnormalities in subjective and objective signs, or physical findings, in any subjects. The intestinal and oropharyngeal bacterial flora were not sig...
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Published in | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 2; no. 4; pp. 271 - 279 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
1996
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Abstract | S-1090, an oral cephem antibiotic, was given to healthy male volunteers in single (10 to 400mg) and multiple (200mg, twice a day) doses. There were no abnormalities in subjective and objective signs, or physical findings, in any subjects. The intestinal and oropharyngeal bacterial flora were not significantly affected by S-1090. These results suggest that S-1090 is a safe and well-tolerated drug. Food intake increased the absorption of S-1090, but did not affect its half-life. The plasma concentration increased with increasing doses, but at a rate less than proportional to the dose, in the single-dose studies. S-1090 was eliminated with a half-life of 2 to 3 hours after oral administration under nonfasting conditions, independent of dose. Urinary recovery rate decreased with increasing doses. The maximum plasma concentration, half-life, and area under the concentration-time curve at the dose of 100mg in nonfasting conditions were 3.78μg/ml, 2.77 hours, and 25.51μg·h/mL, respectively. S-1090 may be absorbed by both unsaturable passive and saturable active transport systems. During multiple dosing, the extent of absorption decreased slightly, but steady state was achieved within several days without changes in half-life. S-1090 binds to serum protein constantly, at a very high 97%, which might cause the long half-life of this drug. The high plasma concentration and long half-life of S-1090 are favorable for clinical use. |
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AbstractList | S-1090, an oral cephem antibiotic, was given to healthy male volunteers in single (10 to 400mg) and multiple (200mg, twice a day) doses. There were no abnormalities in subjective and objective signs, or physical findings, in any subjects. The intestinal and oropharyngeal bacterial flora were not significantly affected by S-1090. These results suggest that S-1090 is a safe and well-tolerated drug. Food intake increased the absorption of S-1090, but did not affect its half-life. The plasma concentration increased with increasing doses, but at a rate less than proportional to the dose, in the single-dose studies. S-1090 was eliminated with a half-life of 2 to 3 hours after oral administration under nonfasting conditions, independent of dose. Urinary recovery rate decreased with increasing doses. The maximum plasma concentration, half-life, and area under the concentration-time curve at the dose of 100mg in nonfasting conditions were 3.78μg/ml, 2.77 hours, and 25.51μg·h/mL, respectively. S-1090 may be absorbed by both unsaturable passive and saturable active transport systems. During multiple dosing, the extent of absorption decreased slightly, but steady state was achieved within several days without changes in half-life. S-1090 binds to serum protein constantly, at a very high 97%, which might cause the long half-life of this drug. The high plasma concentration and long half-life of S-1090 are favorable for clinical use. |
Author | Kimura, Yasuo Nakashima, Mitsuyoshi Sasaki, Shimaru Sendo, Yuji Oguma, Takayoshi Imoto, Hiromichi |
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Keywords | pharmacokinetics phase I clinical studies S-1090 oral cephem antibiotic |
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References | Nishino T, Otsuki M, Inoue R. In vitro and in vivo antibacterial activity of S-1090, a new oral cephalosporin. 35th Intersci Conf Antimicrob Agents Chemother 1995 (abstr 111). Muranushi, Hashimoto, Hirano (bib0095) 1995; 12 Toothaker, Welling (bib0085) 1980; 20 Kimura Y, Nakashimizu H, Murakami K, Koike M, Nishiuchi M, Kuwahara S. S-1090, a new oral cephalosporin II. Pharmacokinetics in animals. 32nd Intersci Conf Antimicrob Agents Chemother 1992 (abstr 184). Doem, Tubert (bib0055) 1987; 25 O'Callaghan, Morris, Kirby, Shingler (bib0050) 1972; 1 Tsuji, Ishii, Ohno, Miyazaki, Yamaguchi (bib0040) 1995; 39 Nakashima, Katagiri, Oguma (bib0060) 1992; 40 Shimada, Matsumoto, Komiya, Shinkai (bib0070) 1992; 40 Sasaki S, Kimura Y, Shimada J, Kuwahara S. In vitro antibacterial activity of S-1090, a new oral cephalosporin, against various bacteria including Saito (bib0080) 1986; 34 35th Intersci Conf Antimicrob Agents Chemother 1995 (abstr 109). Murakami K, Kubota T, Sasaki S, Miwa H, Kimura Y, Komatsu Y, et al. S-1090, a new oral cephalosporin I. Antibacterial activity. 32nd Intersci Conf Antimicrob Agents Chemother 1992 (abstr 183). Williams, Davis, Lowenthal (bib0090) 1993; 77 Kume, Kubota, Kimura, Nakashimizu, Motokawa (bib0005) 1993; 41 Miyazaki S, Tsuji M, Ishii Y, Ohno A, Yamaguchi K. In vivo antibacterial activity of S-1090, a new oral cephalosporin II. 35th Intersci Conf Antimicrob Agents Chemother 1995 (abstr 113). Kimura, Nakano, Yoshida (bib0045) 1987; 35 Shimada, Shishido, Tsumoto (bib0075) 1989; 37 Metzler CM, Elfring GL, McEwen AJ. A users manual for NONLIN and associated programs. The Upjohn Co, Kalamazoo, Mich. Tsuji M, Ishii Y, Ohno A, Miyazaki S, Yamaguchi K. In vitro antibacterial activity of S-1090, a new oral cephalosporin I. 35th Intersci Conf Antimicrob Agents Chemother 1995 (abstr 107). Saito (10.1007/BF02355128_bib0080) 1986; 34 Shimada (10.1007/BF02355128_bib0070) 1992; 40 10.1007/BF02355128_bib0015 Toothaker (10.1007/BF02355128_bib0085) 1980; 20 Muranushi (10.1007/BF02355128_bib0095) 1995; 12 10.1007/BF02355128_bib0035 10.1007/BF02355128_bib0025 Kume (10.1007/BF02355128_bib0005) 1993; 41 Williams (10.1007/BF02355128_bib0090) 1993; 77 Kimura (10.1007/BF02355128_bib0045) 1987; 35 O'Callaghan (10.1007/BF02355128_bib0050) 1972; 1 Tsuji (10.1007/BF02355128_bib0040) 1995; 39 Nakashima (10.1007/BF02355128_bib0060) 1992; 40 Shimada (10.1007/BF02355128_bib0075) 1989; 37 10.1007/BF02355128_bib0020 10.1007/BF02355128_bib0010 10.1007/BF02355128_bib0065 10.1007/BF02355128_bib0030 Doem (10.1007/BF02355128_bib0055) 1987; 25 |
References_xml | – volume: 12 start-page: 1488 year: 1995 end-page: 1492 ident: bib0095 article-title: Transport characteristics of S-1090, a new oral cephem, in rat intestinal brush-border membrane vesicles publication-title: Pharm Rev contributor: fullname: Hirano – volume: 39 start-page: 2544 year: 1995 end-page: 2551 ident: bib0040 article-title: In vitro and in vivo antibacterial activities of S-1090, a new oral cephalosporin publication-title: Antimicrob Agents Chemother contributor: fullname: Yamaguchi – volume: 37 start-page: 208 year: 1989 end-page: 245 ident: bib0075 article-title: Phase I study of cefdinir publication-title: Chemotherpy contributor: fullname: Tsumoto – volume: 41 start-page: 758 year: 1993 end-page: 762 ident: bib0005 article-title: Orally active cephalosporins. IV. Synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl) thiomethylthiocephalosporins publication-title: Chem Pharm Bull contributor: fullname: Motokawa – volume: 34 start-page: 134 year: 1986 end-page: 143 ident: bib0080 article-title: Pharmacokinetic studies on T-2588 publication-title: Chemotherpy contributor: fullname: Saito – volume: 25 start-page: 1380 year: 1987 end-page: 1383 ident: bib0055 article-title: Detection of publication-title: J Clin Microbiol contributor: fullname: Tubert – volume: 40 start-page: 210 year: 1992 end-page: 224 ident: bib0060 article-title: Phase I studies on vancomycin hydrochloride for injection publication-title: Jpn J Chemother contributor: fullname: Oguma – volume: 77 start-page: 815 year: 1993 end-page: 829 ident: bib0090 article-title: The influence of food on the absorption and metabolism of drugs publication-title: Med Clin North Am contributor: fullname: Lowenthal – volume: 1 start-page: 283 year: 1972 end-page: 288 ident: bib0050 article-title: Novel method for detection of publication-title: Antimicrob Agents Chemother contributor: fullname: Shingler – volume: 40 start-page: 105 year: 1992 end-page: 119 ident: bib0070 article-title: Phase I clinical studies on a novel oral cephem antibiotic, ME1207 publication-title: Chemotherapy contributor: fullname: Shinkai – volume: 20 start-page: 173 year: 1980 end-page: 199 ident: bib0085 article-title: The effect of food on drug bioavailability publication-title: Ann Rev Pharmacol Toxicol contributor: fullname: Welling – volume: 35 start-page: 129 year: 1987 end-page: 136 ident: bib0045 article-title: Microbiological assay methods for 6315-S (flomoxef) concentration in body fluid publication-title: Chemotherapy contributor: fullname: Yoshida – ident: 10.1007/BF02355128_bib0065 – volume: 34 start-page: 134 issue: suppl 2 year: 1986 ident: 10.1007/BF02355128_bib0080 article-title: Pharmacokinetic studies on T-2588 publication-title: Chemotherpy contributor: fullname: Saito – volume: 25 start-page: 1380 year: 1987 ident: 10.1007/BF02355128_bib0055 article-title: Detection of β-lactamase activity among clinical isolates of Branhamella catarrhalis with six different β-lactamase assay publication-title: J Clin Microbiol doi: 10.1128/JCM.25.8.1380-1383.1987 contributor: fullname: Doem – volume: 37 start-page: 208 issue: suppl 2 year: 1989 ident: 10.1007/BF02355128_bib0075 article-title: Phase I study of cefdinir publication-title: Chemotherpy contributor: fullname: Shimada – ident: 10.1007/BF02355128_bib0010 – volume: 1 start-page: 283 year: 1972 ident: 10.1007/BF02355128_bib0050 article-title: Novel method for detection of β-lactamase by using a chromogenic cephalosporin substrate publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.1.4.283 contributor: fullname: O'Callaghan – volume: 20 start-page: 173 year: 1980 ident: 10.1007/BF02355128_bib0085 article-title: The effect of food on drug bioavailability publication-title: Ann Rev Pharmacol Toxicol doi: 10.1146/annurev.pa.20.040180.001133 contributor: fullname: Toothaker – volume: 40 start-page: 105 issue: suppl 2 year: 1992 ident: 10.1007/BF02355128_bib0070 article-title: Phase I clinical studies on a novel oral cephem antibiotic, ME1207 publication-title: Chemotherapy contributor: fullname: Shimada – volume: 41 start-page: 758 year: 1993 ident: 10.1007/BF02355128_bib0005 article-title: Orally active cephalosporins. IV. Synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl) thiomethylthiocephalosporins publication-title: Chem Pharm Bull doi: 10.1248/cpb.41.758 contributor: fullname: Kume – volume: 12 start-page: 1488 year: 1995 ident: 10.1007/BF02355128_bib0095 article-title: Transport characteristics of S-1090, a new oral cephem, in rat intestinal brush-border membrane vesicles publication-title: Pharm Rev contributor: fullname: Muranushi – ident: 10.1007/BF02355128_bib0035 – volume: 77 start-page: 815 year: 1993 ident: 10.1007/BF02355128_bib0090 article-title: The influence of food on the absorption and metabolism of drugs publication-title: Med Clin North Am doi: 10.1016/S0025-7125(16)30226-7 contributor: fullname: Williams – ident: 10.1007/BF02355128_bib0030 – volume: 40 start-page: 210 year: 1992 ident: 10.1007/BF02355128_bib0060 article-title: Phase I studies on vancomycin hydrochloride for injection publication-title: Jpn J Chemother contributor: fullname: Nakashima – ident: 10.1007/BF02355128_bib0020 – volume: 39 start-page: 2544 year: 1995 ident: 10.1007/BF02355128_bib0040 article-title: In vitro and in vivo antibacterial activities of S-1090, a new oral cephalosporin publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.39.11.2544 contributor: fullname: Tsuji – ident: 10.1007/BF02355128_bib0015 doi: 10.1128/AAC.39.11.2544 – ident: 10.1007/BF02355128_bib0025 – volume: 35 start-page: 129 year: 1987 ident: 10.1007/BF02355128_bib0045 article-title: Microbiological assay methods for 6315-S (flomoxef) concentration in body fluid publication-title: Chemotherapy contributor: fullname: Kimura |
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Title | Phase I Clinical Studies of S-1090: Safety and Pharmacokinetics |
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