Regulation of Starch Stores by a Ca2+-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii

• Published in: Cell host & microbe Vol. 18; no. 6; pp. 670 - 681
• Main Authors: Uboldi, Alessandro D., McCoy, James M., Blume, Martin, Gerlic, Motti, Ferguson, David J.P., Dagley, Laura F., Beahan, Cherie T., Stapleton, David I., Gooley, Paul R., Bacic, Antony, Masters, Seth L., Webb, Andrew I., McConville, Malcolm J., Tonkin, Christopher J.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 09.12.2015

Transmissible stages of Toxoplasma gondii store energy in the form of the carbohydrate amylopectin. Here, we show that the Ca2+-dependent protein kinase CDPK2 is a critical regulator of amylopectin metabolism. Increased synthesis and loss of degradation of amylopectin in CDPK2 deficient parasites re...