Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and the translation of nuclear-encoded proteins

• Published in: iScience Vol. 27; no. 4; p. 109136
• Main Authors: Cardanho-Ramos, Carlos, Simões, Rúben Alves, Wang, Yi-Zhi, Faria-Pereira, Andreia, Bomba-Warczak, Ewa, Craessaerts, Katleen, Spinazzi, Marco, Savas, Jeffrey N., Morais, Vanessa A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 19.04.2024
• Subjects: Biochemistry; Biological sciences; Cellular neuroscience; Molecular neuroscience; Natural sciences; Neuroscience; Molecular neuroscience; Neuroscience; Biochemistry; Biological sciences; Natural sciences; Cellular neuroscience

In neurons, it is commonly assumed that mitochondrial replication only occurs in the cell body, after which the mitochondria must travel to the neuron’s periphery. However, while mitochondrial DNA replication has been observed to occur away from the cell body, the specific mechanisms involved remain...