Neu1 sialidase regulates heterospecific social interaction in zebrafish via D1 dopamine receptor

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 9; p. 130839
• Main Authors: Tsuji, Sumomo, Ikeda, Asami, Kubo, Yurina, Hyodo, Toshiki, Ishii, Mika, Komatsu, Masaharu, Shiozaki, Kazuhiro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2025
• Subjects: Animals; Behavior, Animal; Brain - metabolism; D1 dopamine receptor; Dopamine - metabolism; Heterospecific social interaction; Neu1 sialidase; Neuraminidase - genetics; Neuraminidase - metabolism; Receptors, Dopamine D1 - antagonists & inhibitors; Receptors, Dopamine D1 - metabolism; Serotonin - metabolism; Sialic Acids - metabolism; Social Interaction; Zebrafish - metabolism; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; Heterospecific social interaction; D1 dopamine receptor; Neu1 sialidase

Neu1 sialidase catalyzes the removal of sialic acids from oligosaccharides and glycoproteins in lysosomes and plasma membranes. Recently, the association between Neu1 and psychiatric disorders, such as manic depression and schizophrenia, has attracted attention. neu1−/− zebrafish (Neu1-KO) exhibit l...