Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance

• Published in: Cell metabolism Vol. 37; no. 4; pp. 936 - 953.e7
• Main Authors: Miro, Caterina, Cicatiello, Annunziata Gaetana, Nappi, Annarita, Sagliocchi, Serena, Acampora, Lucia, Restolfer, Federica, Cuomo, Ornella, de Alteris, Giulia, Pugliese, Gabriella, Torabinejad, Sepehr, Maritato, Rosa, Murolo, Melania, Di Cicco, Emery, Velotti, Nunzio, Capuano, Marianna, La Civita, Evelina, Terracciano, Daniela, Ciampaglia, Roberto, Stornaiuolo, Mariano, Musella, Mario, Aprea, Giovanni, Pignataro, Giuseppe, Savastano, Silvia, Dentice, Monica
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2025
• Subjects: alpha-MSH - metabolism; Animals; Cyclic AMP - metabolism; deiodinases; energy homeostasis; Energy Metabolism - drug effects; glucose uptake; Humans; Iodide Peroxidase - genetics; Iodide Peroxidase - metabolism; Iodothyronine Deiodinase Type II; leptin; Leptin - administration & dosage; Leptin - metabolism; Leptin - pharmacology; Male; melanocortin; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; obesity; Obesity - metabolism; Signal Transduction; skeletal muscle; STAT3 Transcription Factor - metabolism; thyroid hormone; Thyroid Hormones - metabolism; thyroid hormone; glucose uptake; deiodinases; skeletal muscle; leptin; energy homeostasis; obesity; melanocortin
• ISSN: 1550-4131; 1932-7420; 1932-7420
• DOI: 10.1016/j.cmet.2025.01.025

Thyroid hormones (THs) are key modulators of energy metabolism and cross-talk with other endocrine and metabolic factors. Notably, leptin can increase hypothalamic control of TH synthesis as an adaptive metabolic response regulating body weight. In this study, we found that the TH signal is heighten...