Effect of decreasing PEEP on hyperinflation and collapse in COVID-19: A computed tomography study

• Published in: Acta anaesthesiologica Scandinavica Vol. 68; no. 5; pp. 626 - 634
• Main Authors: Santini, Alessandro, Protti, Alessandro, Pennati, Francesca, Dalla Corte, Francesca, Martinetti, Nicolò, Pugliese, Luca, Picardo, Giorgio, Chiurazzi, Chiara, Ferrari, Michele, Costantini, Elena, Aliverti, Andrea, Cecconi, Maurizio
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2024
• Subjects: Aeration; Computed tomography; COVID-19; COVID-19 - therapy; Density; Epidemiology; Humans; Lung - diagnostic imaging; Lung Compliance - physiology; Lungs; Population studies; Positive-Pressure Respiration - methods; Respiration; Respiratory Distress Syndrome; Shock; Tomography; Tomography, X-Ray Computed; Ventilation

High positive end-expiratory pressure (PEEP>10 cmH O) is commonly used in mechanically ventilated hypoxemic patients with COVID-19. However, some epidemiological and physiological studies indirectly suggest that using a lower PEEP may primarily and beneficially decrease lung hyperinflation in thi...