Protective Effect of Selenium and Zinc Against Dehp Induced Toxicity in the Thyroid Gland of Rats

Objective: To compare the efficacy of Selenium and Zinc in improving histological features on DEHP-induced toxicity in the thyroid gland of rats. Design of study: Laboratory based experimental study. Place and Duration of Study: Anatomy Department of Islamic International Medical College with the Na...

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Published inPakistan Armed Forces medical journal Vol. 72; no. 4; pp. 1424 - 27
Main Authors Hussain, Nabiha, Ali, Shabana, Bano, Maleeha, Khursheed, Tooba, Beenish, Huma, Bano, Syeda Sara
Format Journal Article
LanguageEnglish
Published Rawalpindi Knowledge Bylanes 31.08.2022
AsiaNet Pakistan (Pvt) Ltd
Army Medical College Rawalpindi
Subjects
DEHP
Drinking water
Esters
Fast food
Hormones
Hyperplasia
Metabolism
Oxidative stress
Physiology
Rodents
Selenium
Thyroid gland
Variance analysis
Zinc
Islamabad Pakistan
Rawalpindi Pakistan
Pakistan
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Summary:Objective: To compare the efficacy of Selenium and Zinc in improving histological features on DEHP-induced toxicity in the thyroid gland of rats. Design of study: Laboratory based experimental study. Place and Duration of Study: Anatomy Department of Islamic International Medical College with the National Institute of Health (NIH), Islamabad Pakistan cooperation from Sep 2019 to Sep 2020. Methodology: Forty, eight weeks old rats were divided into four groups, each containing ten male rats. In control, Group-A rats were on the standard diet. In Group-B, rats were given orally 500mg/kg/day DEHP. In Group-C rats were given 500mg/kg/day DEHP and 1mg/kg/day Selenium orally. In Group-D rats were given 500mg/kg/day DEHP and 5mg/kg/day Zinc orally. After 28 days, rats were dissected, and the thyroid gland was removed. Histological parameters, vacuolization and number of follicular cells were observed with H and E stining among control and experimental groups. Results: In Group-B, 50% of rats showed severe vacuolization. In Group-C, 60% of rats showed minimal vacuolization. In Group- D, 40% of rats showed minimally, and 40% of rats showed mild vacuolization. Among quantitative parameters, the number of follicular cells was conserved more by Selenium than Zinc. Conclusion: Selenium and Zinc have a protective effect on thyroid histological changes caused by DEHP, but Selenium shows better conservation than zinc on thyroid histology.
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v72i4.8393