Immunohistochemical analysis of chronic and recurrent dermatophytosis
Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particul...
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Published in | Mycoses Vol. 67; no. 3; p. e13714 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Abstract | Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis.
We aimed to compare the population of various immune cells in specimens of chronic recurrent dermatophytosis and those with acute superficial dermatophytosis.
We investigated the density of various immune cells-Langerhans cells (CD1a+), macrophages (CD68+), dermal dendrocytes (Factor XIIIa+) in the skin of chronic dermatophytosis patients and those with successfully resolved lesions (controls).
Langerhans cells were significantly decreased in the epidermis of patients, both in affected and unaffected areas in comparison with controls. In the dermis, however, no differences in the density of immune cells (macrophages and fibroblasts) were observed.
The limited sample size and immune cells evaluated could be expanded further in future research.
These results indicate that the decreased number of Langerhans cells could be a potential risk factor for the development of chronic and recurrent dermatophytosis. |
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AbstractList | Abstract
Background
Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis.
Objectives
We aimed to compare the population of various immune cells in specimens of chronic recurrent dermatophytosis and those with acute superficial dermatophytosis.
Methods
We investigated the density of various immune cells—Langerhans cells (CD1a+), macrophages (CD68+), dermal dendrocytes (Factor XIIIa+) in the skin of chronic dermatophytosis patients and those with successfully resolved lesions (controls).
Results
Langerhans cells were significantly decreased in the epidermis of patients, both in affected and unaffected areas in comparison with controls. In the dermis, however, no differences in the density of immune cells (macrophages and fibroblasts) were observed.
Limitations
The limited sample size and immune cells evaluated could be expanded further in future research.
Conclusion
These results indicate that the decreased number of Langerhans cells could be a potential risk factor for the development of chronic and recurrent dermatophytosis. BACKGROUNDDermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis.OBJECTIVESWe aimed to compare the population of various immune cells in specimens of chronic recurrent dermatophytosis and those with acute superficial dermatophytosis.METHODSWe investigated the density of various immune cells-Langerhans cells (CD1a+), macrophages (CD68+), dermal dendrocytes (Factor XIIIa+) in the skin of chronic dermatophytosis patients and those with successfully resolved lesions (controls).RESULTSLangerhans cells were significantly decreased in the epidermis of patients, both in affected and unaffected areas in comparison with controls. In the dermis, however, no differences in the density of immune cells (macrophages and fibroblasts) were observed.LIMITATIONSThe limited sample size and immune cells evaluated could be expanded further in future research.CONCLUSIONThese results indicate that the decreased number of Langerhans cells could be a potential risk factor for the development of chronic and recurrent dermatophytosis. Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis. We aimed to compare the population of various immune cells in specimens of chronic recurrent dermatophytosis and those with acute superficial dermatophytosis. We investigated the density of various immune cells-Langerhans cells (CD1a+), macrophages (CD68+), dermal dendrocytes (Factor XIIIa+) in the skin of chronic dermatophytosis patients and those with successfully resolved lesions (controls). Langerhans cells were significantly decreased in the epidermis of patients, both in affected and unaffected areas in comparison with controls. In the dermis, however, no differences in the density of immune cells (macrophages and fibroblasts) were observed. The limited sample size and immune cells evaluated could be expanded further in future research. These results indicate that the decreased number of Langerhans cells could be a potential risk factor for the development of chronic and recurrent dermatophytosis. |
Author | Marla, Nisha J Madhumita, Monisha Jayaraman, Jyothi Bhat, Ramesh M |
Author_xml | – sequence: 1 givenname: Ramesh M surname: Bhat fullname: Bhat, Ramesh M organization: Father Muller Medical College, Mangalore, Karnataka, India – sequence: 2 givenname: Monisha orcidid: 0000-0001-5652-8785 surname: Madhumita fullname: Madhumita, Monisha organization: Saveetha Medical College, Chennai, Tamil Nadu, India – sequence: 3 givenname: Nisha J surname: Marla fullname: Marla, Nisha J organization: Father Muller Medical College, Mangalore, Karnataka, India – sequence: 4 givenname: Jyothi surname: Jayaraman fullname: Jayaraman, Jyothi organization: Father Muller Medical College, Mangalore, Karnataka, India |
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Cites_doi | 10.3390/jof6040238 10.4269/ajtmh.21-1022 10.3389/fimmu.2020.605644 10.1111/myc.13360 10.3390/jof8010039 10.1590/s1678-9946201961056 10.1099/jmm.0.000982 10.25259/IJDVL_301_20 10.1111/j.1439-0507.2008.01606.x 10.1111/myc.13246 10.1111/myc.13322 10.1016/j.jid.2018.07.040 |
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References | e_1_2_14_2_1 Tuknayat A (e_1_2_14_12_1) 2020; 13 e_1_2_14_4_1 e_1_2_14_3_1 e_1_2_14_11_1 e_1_2_14_10_1 e_1_2_14_13_1 e_1_2_14_15_1 e_1_2_14_14_1 e_1_2_14_6_1 e_1_2_14_5_1 e_1_2_14_7_1 Gupta C (e_1_2_14_8_1) 2022; 33 e_1_2_14_9_1 |
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Snippet | Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors... Abstract Background Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions.... BackgroundDermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various... BACKGROUNDDermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various... |
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SubjectTerms | Cell size Dermatomycosis Dermis Epidermis Factor XIIIa Humans Langerhans Cells Macrophages Risk factors Skin - pathology Tinea - pathology Tropical environment |
Title | Immunohistochemical analysis of chronic and recurrent dermatophytosis |
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