Evaluation of red blood cell lipoperoxidation in hemodialysed patients during erythropoietin therapy supplemented or not with iron

• Published in: Nephron (2015) Vol. 69; no. 4; p. 404
• Main Authors: Delmas-Beauvieux, M C, Combe, C, Peuchant, E, Carbonneau, M A, Dubourg, L, de Précigout, V, Aparicio, M, Clerc, M
• Format: Journal Article
• Language: English
• Published: Switzerland 1995
• Subjects: Adult; Aged; Anemia - blood; Anemia - drug therapy; Anemia - etiology; Catalase - blood; Erythrocytes - drug effects; Erythrocytes - metabolism; Erythropoietin - therapeutic use; Fatty Acids, Unsaturated - blood; Female; Glutathione Peroxidase - blood; Humans; Iron - administration & dosage; Lipid Peroxidation - drug effects; Male; Malondialdehyde - blood; Middle Aged; Renal Dialysis - adverse effects; Superoxide Dismutase - blood; Uremia - blood; Uremia - complications; Uremia - therapy

To investigate the effects of erythropoietin (rHuEPO) therapy supplemented or not with iron on hemolysis in hemodialysed patients (HD) we evaluated lipoperoxidation (LPO) by assaying (i) the red blood cell (RBC) antioxidant enzymatic system including superoxide dismutase (SOD), glutathione peroxidas...