Synthesis and antiproliferative activity in vitro of 2-aminobenzimidazole derivatives

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 59; no. 2; pp. 83 - 91
• Main Authors: Nawrocka, Wanda, Sztuba, Barbara, Kowalska, Maria W, Liszkiewicz, Hanna, Wietrzyk, Joanna, Nasulewicz, Anna, Pełczyńska, Marzena, Opolski, Adam
• Format: Journal Article
• Language: English
• Published: France Elsevier SAS 01.02.2004
• Subjects: 2-Aminobenzimidazole derivatives; 2-Benzylamino-1-cinnamoylbenzimidazole; 2-Benzylaminobenzimidazoles; 2-Benzylidene; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Antiproliferative activity in vitro; Benzimidazoles - chemical synthesis; Benzimidazoles - pharmacology; Cell Division - drug effects; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Pyrimido[1,2-a]benzimidazol-4-ones; Rhodamines; Schiff bases; Schiff Bases - chemistry; Schiff Bases - pharmacology; Spectrophotometry, Infrared; Schiff bases; 2-Benzylidene; 2-Benzylaminobenzimidazoles; 2-Aminobenzimidazole derivatives; Pyrimido[1,2-a]benzimidazol-4-ones; Antiproliferative activity in vitro; 2-Benzylamino-1-cinnamoylbenzimidazole

A novel series of Schiff bases 1–11, the derivatives of 2-aminobenzimidazole and substituted aromatic aldehydes, has been synthesised. Compounds 1–11 reduced by NaBH 4 formed 2-benzylaminobenzimidazoles 12–21. 2-( o-Bromobenzylamino)benzimidazole ( 15) acylated by cinnamoyl chloride gave 2-( o-bromo...