Mcl-1 in Transgenic Mice Promotes Survival in a Spectrum of Hematopoietic Cell Types and Immortalization in the Myeloid Lineage

• Published in: Blood Vol. 92; no. 9; pp. 3226 - 3239
• Main Authors: Zhou, Ping, Qian, Liping, Bieszczad, Christine K., Noelle, Randolph, Binder, Michael, Levy, Norman B., Craig, Ruth W.
• Format: Journal Article
• Language: English; Japanese
• Published: 01.11.1998

Mcl-1 is a member of the Bcl-2 family that is expressed in early monocyte differentiation and that can promote viability on transfection into immature myeloid cells. However, the effects of Mcl-1 are generally short lived compared with those of Bcl-2 and are not obvious in some transfectants. To fur...