STAT5 signaling in normal and pathologic hematopoiesis

• Published in: Frontiers in bioscience Vol. 12; no. 1; pp. 2807 - 2820
• Main Author: Bunting, Kevin D
• Format: Journal Article
• Language: English
• Published: United States 01.05.2007
• Subjects: Adaptor Proteins, Signal Transducing - physiology; Animals; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - physiology; Humans; Signal Transduction; STAT5 Transcription Factor - metabolism

Hematopoietic development is highly dependent upon cytokine/receptor initiated signaling pathways. Of those activated in hematopoietic cells, the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays a major role. This review focuses on the key role of STAT5 activa...