Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail

• Published in: Biochemical journal Vol. 473; no. 3; p. 285
• Main Authors: Yang, Yifei, Hodsdon, Michael E, Lolis, Elias J, Ehrlich, Barbara E
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Amino Acid Sequence; Calcium - metabolism; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Tertiary; TRPP Cation Channels - chemistry; TRPP Cation Channels - genetics; TRPP Cation Channels - metabolism; Ca2+-binding proteins; polycystin-2; hydrogen–deuterium exchange mass spectrometry; isothermal titration calorimetry; nuclear magnetic resonance

PC2 (polycystin-2) forms a Ca(2+)-permeable channel in the cell membrane and its function is regulated by cytosolic Ca(2+) levels. Mutations in the C-terminal tail of human PC2 (HPC2 Cterm) lead to autosomal dominant polycystic kidney disease. The HPC2 Cterm protein contains a Ca(2+)-binding site re...