Refractory Infection of Mycobacterium abscessus: Skin and Soft Tissue Infection Recurred under Combination Therapy of Surgery and Outpatient Antibiotics

Mycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes skin and soft tissue infections. Treatment methods for these infections, including the type and duration of antimicrobial agents, have not been established. The function of surgery is also unknown. We report a case...

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Published inJournal of Plastic and Reconstructive Surgery p. 2023-0055
Main Authors Yamada, Atsuki, Yukawa, Ken, Eguchi, Tomoaki
Format Journal Article
LanguageEnglish
Published Japan Society of Plastic and Reconstructive Surgery 2024
Subjects
antibiotics
Mycobacterium abscessus
skin and soft tissue infection
surgery
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Abstract Mycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes skin and soft tissue infections. Treatment methods for these infections, including the type and duration of antimicrobial agents, have not been established. The function of surgery is also unknown. We report a case of skin and soft tissue infection of the left upper arm in a healthy 47-year-old Japanese man who was treated with complete surgical excision and antimicrobial therapy as feasible on an outpatient basis, which resulted in relapse <1 month later. Given the possibility of developing antibiotic-resistant bacteria, insufficient antimicrobial treatment should not be administered without careful consideration. There are currently few effective oral antimicrobial agents against M. abscessus, so careful antimicrobial therapy along with hospitalization (at least during the early treatment phase) is preferred, regardless of the use/nonuse of surgical treatment.
AbstractList Mycobacterium abscessus (M. abscessus) is a nontuberculous mycobacterium that causes skin and soft tissue infections. Treatment methods for these infections, including the type and duration of antimicrobial agents, have not been established. The function of surgery is also unknown. We report a case of skin and soft tissue infection of the left upper arm in a healthy 47-year-old Japanese man who was treated with complete surgical excision and antimicrobial therapy as feasible on an outpatient basis, which resulted in relapse <1 month later. Given the possibility of developing antibiotic-resistant bacteria, insufficient antimicrobial treatment should not be administered without careful consideration. There are currently few effective oral antimicrobial agents against M. abscessus, so careful antimicrobial therapy along with hospitalization (at least during the early treatment phase) is preferred, regardless of the use/nonuse of surgical treatment.
ArticleNumber 2023-0055
Author Yamada, Atsuki
Yukawa, Ken
Eguchi, Tomoaki
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10.1038/s41579-020-0331-1
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SubjectTerms antibiotics
Mycobacterium abscessus
skin and soft tissue infection
surgery
Title Refractory Infection of Mycobacterium abscessus: Skin and Soft Tissue Infection Recurred under Combination Therapy of Surgery and Outpatient Antibiotics
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