Inhibition of YAP/TAZ-TEAD activity induces cytotrophoblast differentiation into syncytiotrophoblast in human trophoblast

• Published in: Molecular human reproduction Vol. 28; no. 10
• Main Authors: Mizutani, Tetsuya, Orisaka, Makoto, Miyazaki, Yumiko, Morichika, Ririko, Uesaka, Miki, Miyamoto, Kaoru, Yoshida, Yoshio
• Format: Journal Article
• Language: English
• Published: 29.09.2022

During placentation, placental cytotrophoblast (CT) cells differentiate into syncytiotrophoblast (ST) cells and extravillous trophoblast (EVT) cells. In the placenta, the expression of various genes is regulated by the Hippo pathway through a transcription complex, Yes-associated protein (YAP)/trans...