Detection of Opiate Use in a Methadone Maintenance Treatment Population with the CEDIA® 6-Acetylmorphine and CEDIA DAU Opiate Assays

• Published in: Journal of analytical toxicology Vol. 25; no. 7; pp. 515 - 519
• Main Authors: Spanbauer, Alan C., Casseday, Scott, Davoudzadeh, David, Preston, Kenzie L., Huestis, Marilyn A.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2001
• Subjects: Adolescent; Adult; Cocaine-Related Disorders - diagnosis; Cocaine-Related Disorders - therapy; Codeine - urine; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Heroin Dependence - diagnosis; Heroin Dependence - therapy; Humans; Immunoenzyme Techniques - methods; Immunoenzyme Techniques - standards; Male; Methadone - therapeutic use; Middle Aged; Morphine - urine; Morphine Derivatives - urine; Narcotics - therapeutic use; Narcotics - urine; Sensitivity and Specificity; Substance Abuse Detection - methods; Workplace

Heroin, with a plasma half-life of approximately 5 min, is rapidly metabolized to 6-acetylmorphine (6-AM). 6-AM, a specific marker for heroin use, which also has a short half-life of only 0.6 h, is detected in urine for only a few hours after heroin exposure. Ingestion of poppy seeds and/or licit op...