Biological properties of Cis- and Trans- dichlorodiammineplatinum

Cis- and Trans- dichlorodiammineplatinum (II) inhibit the development of the sea urchin eggs. The inhibition is prevented by N-acetylcysteine, glutathione and α-mercaptopropionylglycine. Sulfhydril groups appear as a cellular target for these platinum compounds.

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Bibliographic Details
Published inCell biology international reports Vol. 4; no. 7; pp. 697 - 700
Main Author Lallier, R.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.07.1980
Subjects
Acetylcysteine - pharmacology
Animals
Blastocyst - drug effects
Cisplatin - pharmacology
Female
Gastrula - drug effects
Glutathione - pharmacology
Sea Urchins
Stereoisomerism
Tiopronin - pharmacology
Zygote - cytology
Zygote - drug effects
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Summary:Cis- and Trans- dichlorodiammineplatinum (II) inhibit the development of the sea urchin eggs. The inhibition is prevented by N-acetylcysteine, glutathione and α-mercaptopropionylglycine. Sulfhydril groups appear as a cellular target for these platinum compounds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0309-1651
1878-240X
DOI:10.1016/0309-1651(80)90210-6