An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium

• Published in: Antiviral research Vol. 9; no. 4; p. 263
• Main Authors: Imperia, P S, Lazarus, H M, Dunkel, E C, Pavan-Langston, D, Geary, P A, Lass, J H
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.1988
• Subjects: Animals; Antiviral Agents - toxicity; Bromodeoxyuridine - analogs & derivatives; Bromodeoxyuridine - toxicity; Cell Survival - drug effects; Cornea - drug effects; Cornea - metabolism; Deoxyuridine - analogs & derivatives; Deoxyuridine - toxicity; Epithelium - drug effects; Epithelium - metabolism; Idoxuridine - toxicity; In Vitro Techniques; Rabbits; Thymidine - metabolism; Trifluridine - toxicity

Using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine (IDU), trifluridine (TFT), ethyldeoxyuridine (EDU), and (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU). Confluent rabbit corneal epithelial cell cultures were est...