Immediate-release tablet formulation of rebamipide and a pharmacokinetic study in healthy human subjects

• Published in: International journal of clinical pharmacology and therapeutics Vol. 61; no. 6; pp. 273 - 288
• Main Authors: Won, Yong-Hoon, Goo, Yoon Tae, Sin, Gi Hyeong, Hong, Sun Ho, Kim, Chang Hyun, Kim, Min-Ju, Lee, Tae Hwa, Choi, Young Wook
• Format: Journal Article
• Language: English
• Published: Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.06.2023
• Subjects: Area Under Curve; Biological Availability; Cross-Over Studies; Healthy Volunteers; Human subjects; Humans; Male; Pharmacokinetics; Powders; Scanning electron microscopy; Tablets; Therapeutic Equivalency

To develop an immediate-release tablet preparation containing rebamipide (RBM) and perform the bioavailability assessment in the healthy human subjects. Raw RBM powder was characterized using differential scanning calorimetry, powder X-ray diffraction, and scanning electron microscopy (SEM). RBM tab...