Povidone-iodine and chlorhexidine gluconate-containing detergents for disinfection of hands

The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent iso-propanol on to the hands for 1 min was used as a standard for ‘hygienic’ disinfection, with Escherichia coli as the test organism. The mean...

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Published inThe Journal of hospital infection Vol. 1; no. 2; pp. 149 - 158
Main Authors Rotter, M., Koller, W., Wewalka, G.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.1980
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Abstract The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent iso-propanol on to the hands for 1 min was used as a standard for ‘hygienic’ disinfection, with Escherichia coli as the test organism. The mean log reduction obtained was 3.16 with povidone-iodine and 2.92 with chlorhexidine. These were considerably less than obtained with iso-propanol which produced a reduction of 4.23 and 4.30 orders of magnitude. In the ‘surgical’ hand disinfection tests, a 5 min wash with povidone-iodine and a 3 min wash with chlorhexidine detergent were compared with rubbing 60 per cent n-propanol or iso-propanol on to the hands for 5 min; n-propanol was taken as the standard preparation. Immediately after disinfection the log reduction in the resident flora was 0.92 with povidone-iodine and 0.78 with chlorhexidine, whereas n-propanol gave a log reduction of 3.43. After wearing a surgical glove for 3 h a log reduction of 0.24 was obtained with povidoneiodine, 0.75 with chlorhexidine and 2.94 with n-propanol. Treatment with iso-propanol gave a log reduction of 1.04. Thus, alcohols are shown by these tests to be far more effective than povidone-iodine or chlorhexidine detergent preparations in ‘hygienic’ as well as ‘surgical’ hand disinfection.
AbstractList The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent iso-propanol on to the hands for 1 min was used as a standard for ‘hygienic’ disinfection, with Escherichia coli as the test organism. The mean log reduction obtained was 3.16 with povidone-iodine and 2.92 with chlorhexidine. These were considerably less than obtained with iso-propanol which produced a reduction of 4.23 and 4.30 orders of magnitude. In the ‘surgical’ hand disinfection tests, a 5 min wash with povidone-iodine and a 3 min wash with chlorhexidine detergent were compared with rubbing 60 per cent n-propanol or iso-propanol on to the hands for 5 min; n-propanol was taken as the standard preparation. Immediately after disinfection the log reduction in the resident flora was 0.92 with povidone-iodine and 0.78 with chlorhexidine, whereas n-propanol gave a log reduction of 3.43. After wearing a surgical glove for 3 h a log reduction of 0.24 was obtained with povidoneiodine, 0.75 with chlorhexidine and 2.94 with n-propanol. Treatment with iso-propanol gave a log reduction of 1.04. Thus, alcohols are shown by these tests to be far more effective than povidone-iodine or chlorhexidine detergent preparations in ‘hygienic’ as well as ‘surgical’ hand disinfection.
Author Koller, W.
Rotter, M.
Wewalka, G.
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  year: 1977
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  article-title: Eignung dreier Aklohole für eine Standard-Desinfektionsmethode in der Wertbestimmung von Verfahren für die Hygienische Händedesinfektion
  publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B
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– volume: 161
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  year: 1975
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  article-title: Zur Erstellung von Anforderungen an Verfahren zur Hygienischen Händedesinfektion
  publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B
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  year: 1976
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  article-title: Application of a gloved-hand model for multiparameter measurements of skin degerming activity
  publication-title: Journal of Clinical Microbiology
  doi: 10.1128/jcm.3.4.406-413.1976
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  article-title: A test for ‘hygienic’ hand disinfection
  publication-title: Journal of Clinical Infection
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    fullname: Ayliffe
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  year: 1977
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  article-title: Test-methode für die Wertbemessung von Verfahren für die Hygienische Händedesinfektion. 1. Teil: Beschreibung der Methode
  publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B
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  year: 1972
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  article-title: Zur Chirurgischen Händedesinfektion mit einem Jodophor (Betadine)
  publication-title: Schweizerische medizinische Wochenschrift
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    fullname: Müntener
– volume: 75
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  article-title: Comparison of two methods for assessing the removal of total organisms from the skin
  publication-title: Journal of Hygiene (Cambridge)
  doi: 10.1017/S002217240004729X
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  publication-title: Lancet
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  article-title: Zur Kinetik der Keimabgabe von der künstlich kontaminierten Hand
  publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B
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    fullname: Koller
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  publication-title: British Medical Journal
  doi: 10.1136/bmj.2.1546.377
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  doi: 10.1136/jcp.31.10.919
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  article-title: Limits to progressive reduction of resident skin bacteria by disinfection
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  article-title: Shedding of bacteria and skin squames after handwashing
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  article-title: Delayed antimicrobial effects of skin disinfection by alcohol
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  article-title: A partial substitute for hand washing
  publication-title: Nursing Times
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  article-title: Untersuchungen zum Modell der küntslich kontaminierten Hand—Vorschlag für eine Prüfmethode
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  article-title: Test-methode für die Wertbemessung von Verfahren für die Hygienische Händedesinfektion. 2. Teil: Begründungen und Erläuterungen anhand eines Anwendungsbeispieles
  publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B
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  article-title: Clean air, less infection
  publication-title: Hospital Engineering
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  publication-title: Journal of Hygiene (Cambridge)
  doi: 10.1017/S002217240002550X
  contributor:
    fullname: Lilly
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Snippet The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent...
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StartPage 149
SubjectTerms Chlorhexidine - analogs & derivatives
Chlorhexidine - pharmacology
Detergents - pharmacology
Escherichia coli - drug effects
Hand - microbiology
Hand Disinfection - methods
Humans
Povidone - analogs & derivatives
Povidone-Iodine - pharmacology
Staphylococcus aureus - drug effects
Surface-Active Agents - pharmacology
Title Povidone-iodine and chlorhexidine gluconate-containing detergents for disinfection of hands
URI https://dx.doi.org/10.1016/0195-6701(80)90047-X
https://www.ncbi.nlm.nih.gov/pubmed/6182205
https://search.proquest.com/docview/75544199
Volume 1
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