Povidone-iodine and chlorhexidine gluconate-containing detergents for disinfection of hands
The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent iso-propanol on to the hands for 1 min was used as a standard for ‘hygienic’ disinfection, with Escherichia coli as the test organism. The mean...
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Published in | The Journal of hospital infection Vol. 1; no. 2; pp. 149 - 158 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.06.1980
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Subjects | |
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Abstract | The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent
iso-propanol on to the hands for 1 min was used as a standard for ‘hygienic’ disinfection, with
Escherichia coli as the test organism. The mean log reduction obtained was 3.16 with povidone-iodine and 2.92 with chlorhexidine. These were considerably less than obtained with
iso-propanol which produced a reduction of 4.23 and 4.30 orders of magnitude. In the ‘surgical’ hand disinfection tests, a 5 min wash with povidone-iodine and a 3 min wash with chlorhexidine detergent were compared with rubbing 60 per cent
n-propanol or
iso-propanol on to the hands for 5 min;
n-propanol was taken as the standard preparation. Immediately after disinfection the log reduction in the resident flora was 0.92 with povidone-iodine and 0.78 with chlorhexidine, whereas
n-propanol gave a log reduction of 3.43. After wearing a surgical glove for 3 h a log reduction of 0.24 was obtained with povidoneiodine, 0.75 with chlorhexidine and 2.94 with
n-propanol. Treatment with
iso-propanol gave a log reduction of 1.04. Thus, alcohols are shown by these tests to be far more effective than povidone-iodine or chlorhexidine detergent preparations in ‘hygienic’ as well as ‘surgical’ hand disinfection. |
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AbstractList | The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent
iso-propanol on to the hands for 1 min was used as a standard for ‘hygienic’ disinfection, with
Escherichia coli as the test organism. The mean log reduction obtained was 3.16 with povidone-iodine and 2.92 with chlorhexidine. These were considerably less than obtained with
iso-propanol which produced a reduction of 4.23 and 4.30 orders of magnitude. In the ‘surgical’ hand disinfection tests, a 5 min wash with povidone-iodine and a 3 min wash with chlorhexidine detergent were compared with rubbing 60 per cent
n-propanol or
iso-propanol on to the hands for 5 min;
n-propanol was taken as the standard preparation. Immediately after disinfection the log reduction in the resident flora was 0.92 with povidone-iodine and 0.78 with chlorhexidine, whereas
n-propanol gave a log reduction of 3.43. After wearing a surgical glove for 3 h a log reduction of 0.24 was obtained with povidoneiodine, 0.75 with chlorhexidine and 2.94 with
n-propanol. Treatment with
iso-propanol gave a log reduction of 1.04. Thus, alcohols are shown by these tests to be far more effective than povidone-iodine or chlorhexidine detergent preparations in ‘hygienic’ as well as ‘surgical’ hand disinfection. |
Author | Koller, W. Rotter, M. Wewalka, G. |
Author_xml | – sequence: 1 givenname: M. surname: Rotter fullname: Rotter, M. – sequence: 2 givenname: W. surname: Koller fullname: Koller, W. – sequence: 3 givenname: G. surname: Wewalka fullname: Wewalka, G. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6182205$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1093/infdis/63.3.301 10.1128/jcm.3.4.406-413.1976 10.1017/S002217240004729X 10.1016/S0140-6736(65)91609-0 10.1136/bmj.2.1546.377 10.1136/bmj.2.5403.230 10.1136/jcp.31.10.919 10.1136/jcp.32.4.382 10.1017/S0022172400053808 10.1017/S0022172400054024 10.1017/S002217240002550X |
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References_xml | – year: 1978 ident: BIB4 publication-title: National nosocomial infections study report—annual report 1976 contributor: fullname: Center for Disease Control – volume: 31 start-page: 923 year: 1978 end-page: 928 ident: BIB3 article-title: A test for ‘hygienic’ hand disinfection publication-title: Journal of Clinical Infection contributor: fullname: Quoraishi – volume: ii start-page: 377 year: 1890 ident: BIB14 publication-title: British Medical Journal contributor: fullname: Lister – volume: 163 start-page: 509 year: 1976 end-page: 523 ident: BIB6 article-title: Zur Kinetik der Keimabgabe von der künstlich kontaminierten Hand publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Wewalka – volume: 102 start-page: 699 year: 1972 end-page: 706 ident: BIB19 article-title: Zur Chirurgischen Händedesinfektion mit einem Jodophor (Betadine) publication-title: Schweizerische medizinische Wochenschrift contributor: fullname: Reber – volume: 2 start-page: 230 year: 1964 end-page: 233 ident: BIB15 article-title: Disinfection of hands: removal of transient organisms publication-title: British Medical Journal contributor: fullname: Bull – volume: 4 start-page: 242 year: 1949 end-page: 244 ident: BIB1 publication-title: Höchst wichtige Erfahrungen über die Ätiologie der in Gebäranstalten epidemischen Puerperalfieber – volume: 160 start-page: 163 year: 1975 end-page: 172 ident: BIB18 article-title: Vergleich der Wirkung von Wasser, einigen Detergentien und Äthylalkohol auf die transiente Flora der Hände publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Rotter – volume: 164 start-page: 428 year: 1977 end-page: 438 ident: BIB21 article-title: Eignung dreier Aklohole für eine Standard-Desinfektionsmethode in der Wertbestimmung von Verfahren für die Hygienische Händedesinfektion publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Kundi – volume: 81 start-page: 99 year: 1978 end-page: 105 ident: BIB16 article-title: Shedding of bacteria and skin squames after handwashing publication-title: Journal of Hygiene (Cambridge) contributor: fullname: Yeo – volume: 75 start-page: 259 year: 1975 end-page: 274 ident: BIB2 article-title: Comparison of two methods for assessing the removal of total organisms from the skin publication-title: Journal of Hygiene (Cambridge) contributor: fullname: Wilkins – volume: 72 start-page: 332 year: 1976 ident: BIB8 article-title: A partial substitute for hand washing publication-title: Nursing Times contributor: fullname: Boxhall – volume: 31 start-page: 919 year: 1978 end-page: 922 ident: BIB10 article-title: Transient skin flora—their removal by cleansing or disinfection in relation to their mode of deposition publication-title: Journal of Clinical Pathology contributor: fullname: Lowbury – volume: 82 start-page: 497 year: 1979 end-page: 500 ident: BIB13 article-title: Delayed antimicrobial effects of skin disinfection by alcohol publication-title: Journal of Hygiene (Cambridge) contributor: fullname: Zaggy – volume: 63 start-page: 301 year: 1938 end-page: 318 ident: BIB20 article-title: The bacteriology of normal skin; a new quantitative test applied to a study of the bacterial flora and the disinfectant action of mechanical cleaning publication-title: Journal of Infectious Diseases contributor: fullname: Price – volume: 164 start-page: 498 year: 1977 end-page: 506 ident: BIB22 article-title: Test-methode für die Wertbemessung von Verfahren für die Hygienische Händedesinfektion. publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Mittermayer – volume: i start-page: 478 year: 1965 ident: BIB25 article-title: Increased dispersal of skin bacteria into the air after shower-baths publication-title: Lancet contributor: fullname: Shooter – volume: 82 start-page: 89 year: 1979 end-page: 93 ident: BIB11 article-title: Detergents compared with each other and with antiseptics as skin ‘degerming’ agents publication-title: Journal of Hygiene (Cambridge) contributor: fullname: Wilkins – volume: October start-page: 9 year: 1976 end-page: 17 ident: BIB9 article-title: Clean air, less infection publication-title: Hospital Engineering contributor: fullname: Lidwell – volume: 159 start-page: 560 year: 1974 end-page: 581 ident: BIB23 article-title: Untersuchungen zum Modell der küntslich kontaminierten Hand—Vorschlag für eine Prüfmethode publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Kundi – volume: 164 start-page: 509 year: 1977 end-page: 520 ident: BIB5 article-title: Test-methode für die Wertbemessung von Verfahren für die Hygienische Händedesinfektion. 2. Teil: Begründungen und Erläuterungen anhand eines Anwendungsbeispieles publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Wewalka – volume: 32 start-page: 382 year: 1979 end-page: 385 ident: BIB12 article-title: Limits to progressive reduction of resident skin bacteria by disinfection publication-title: Journal of Clinical Pathology contributor: fullname: Wilkins – year: 1956 ident: BIB24 publication-title: Non-parametric Statistics for the Behavioural Sciences contributor: fullname: Siegel – volume: 161 start-page: 165 year: 1975 end-page: 177 ident: BIB7 article-title: Zur Erstellung von Anforderungen an Verfahren zur Hygienischen Händedesinfektion publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Rotter – volume: 3 start-page: 406 year: 1976 end-page: 413 ident: BIB17 article-title: Application of a gloved-hand model for multiparameter measurements of skin degerming activity publication-title: Journal of Clinical Microbiology contributor: fullname: Goss – volume: 63 start-page: 301 year: 1938 ident: 10.1016/0195-6701(80)90047-X_BIB20 article-title: The bacteriology of normal skin; a new quantitative test applied to a study of the bacterial flora and the disinfectant action of mechanical cleaning publication-title: Journal of Infectious Diseases doi: 10.1093/infdis/63.3.301 contributor: fullname: Price – volume: 164 start-page: 428 year: 1977 ident: 10.1016/0195-6701(80)90047-X_BIB21 article-title: Eignung dreier Aklohole für eine Standard-Desinfektionsmethode in der Wertbestimmung von Verfahren für die Hygienische Händedesinfektion publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Rotter – volume: 161 start-page: 165 year: 1975 ident: 10.1016/0195-6701(80)90047-X_BIB7 article-title: Zur Erstellung von Anforderungen an Verfahren zur Hygienischen Händedesinfektion publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Kundi – volume: 3 start-page: 406 year: 1976 ident: 10.1016/0195-6701(80)90047-X_BIB17 article-title: Application of a gloved-hand model for multiparameter measurements of skin degerming activity publication-title: Journal of Clinical Microbiology doi: 10.1128/jcm.3.4.406-413.1976 contributor: fullname: Michaud – volume: 31 start-page: 923 year: 1978 ident: 10.1016/0195-6701(80)90047-X_BIB3 article-title: A test for ‘hygienic’ hand disinfection publication-title: Journal of Clinical Infection contributor: fullname: Ayliffe – volume: 164 start-page: 498 year: 1977 ident: 10.1016/0195-6701(80)90047-X_BIB22 article-title: Test-methode für die Wertbemessung von Verfahren für die Hygienische Händedesinfektion. 1. Teil: Beschreibung der Methode publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Rotter – volume: 102 start-page: 699 year: 1972 ident: 10.1016/0195-6701(80)90047-X_BIB19 article-title: Zur Chirurgischen Händedesinfektion mit einem Jodophor (Betadine) publication-title: Schweizerische medizinische Wochenschrift contributor: fullname: Müntener – volume: 75 start-page: 259 year: 1975 ident: 10.1016/0195-6701(80)90047-X_BIB2 article-title: Comparison of two methods for assessing the removal of total organisms from the skin publication-title: Journal of Hygiene (Cambridge) doi: 10.1017/S002217240004729X contributor: fullname: Ayliffe – volume: i start-page: 478 year: 1965 ident: 10.1016/0195-6701(80)90047-X_BIB25 article-title: Increased dispersal of skin bacteria into the air after shower-baths publication-title: Lancet doi: 10.1016/S0140-6736(65)91609-0 contributor: fullname: Speers – volume: 163 start-page: 509 year: 1976 ident: 10.1016/0195-6701(80)90047-X_BIB6 article-title: Zur Kinetik der Keimabgabe von der künstlich kontaminierten Hand publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Koller – volume: ii start-page: 377 year: 1890 ident: 10.1016/0195-6701(80)90047-X_BIB14 publication-title: British Medical Journal doi: 10.1136/bmj.2.1546.377 contributor: fullname: Lister – volume: 2 start-page: 230 year: 1964 ident: 10.1016/0195-6701(80)90047-X_BIB15 article-title: Disinfection of hands: removal of transient organisms publication-title: British Medical Journal doi: 10.1136/bmj.2.5403.230 contributor: fullname: Lowbury – volume: 31 start-page: 919 year: 1978 ident: 10.1016/0195-6701(80)90047-X_BIB10 article-title: Transient skin flora—their removal by cleansing or disinfection in relation to their mode of deposition publication-title: Journal of Clinical Pathology doi: 10.1136/jcp.31.10.919 contributor: fullname: Lilly – volume: 32 start-page: 382 year: 1979 ident: 10.1016/0195-6701(80)90047-X_BIB12 article-title: Limits to progressive reduction of resident skin bacteria by disinfection publication-title: Journal of Clinical Pathology doi: 10.1136/jcp.32.4.382 contributor: fullname: Lilly – volume: 81 start-page: 99 year: 1978 ident: 10.1016/0195-6701(80)90047-X_BIB16 article-title: Shedding of bacteria and skin squames after handwashing publication-title: Journal of Hygiene (Cambridge) doi: 10.1017/S0022172400053808 contributor: fullname: Meers – volume: 82 start-page: 497 year: 1979 ident: 10.1016/0195-6701(80)90047-X_BIB13 article-title: Delayed antimicrobial effects of skin disinfection by alcohol publication-title: Journal of Hygiene (Cambridge) doi: 10.1017/S0022172400054024 contributor: fullname: Lilly – volume: 160 start-page: 163 year: 1975 ident: 10.1016/0195-6701(80)90047-X_BIB18 article-title: Vergleich der Wirkung von Wasser, einigen Detergentien und Äthylalkohol auf die transiente Flora der Hände publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Mittermayer – volume: 72 start-page: 332 year: 1976 ident: 10.1016/0195-6701(80)90047-X_BIB8 article-title: A partial substitute for hand washing publication-title: Nursing Times contributor: fullname: Kurtz – year: 1978 ident: 10.1016/0195-6701(80)90047-X_BIB4 contributor: fullname: Center for Disease Control – volume: 4 start-page: 242 year: 1949 ident: 10.1016/0195-6701(80)90047-X_BIB1 publication-title: Zeitschriftder k.k. Gesellsch. d.Arztë zu Wien – volume: 159 start-page: 560 year: 1974 ident: 10.1016/0195-6701(80)90047-X_BIB23 article-title: Untersuchungen zum Modell der küntslich kontaminierten Hand—Vorschlag für eine Prüfmethode publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Rotter – year: 1956 ident: 10.1016/0195-6701(80)90047-X_BIB24 contributor: fullname: Siegel – volume: 164 start-page: 509 year: 1977 ident: 10.1016/0195-6701(80)90047-X_BIB5 article-title: Test-methode für die Wertbemessung von Verfahren für die Hygienische Händedesinfektion. 2. Teil: Begründungen und Erläuterungen anhand eines Anwendungsbeispieles publication-title: Zentralblatt für Bakteriologie und Hygiene, 1, Abteilung Originale B contributor: fullname: Koller – volume: October start-page: 9 year: 1976 ident: 10.1016/0195-6701(80)90047-X_BIB9 article-title: Clean air, less infection publication-title: Hospital Engineering contributor: fullname: Lidwell – volume: 82 start-page: 89 year: 1979 ident: 10.1016/0195-6701(80)90047-X_BIB11 article-title: Detergents compared with each other and with antiseptics as skin ‘degerming’ agents publication-title: Journal of Hygiene (Cambridge) doi: 10.1017/S002217240002550X contributor: fullname: Lilly |
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Snippet | The efficacy of a povidone-iodine and a chlorhexidine gluconate detergent was evaluated for ‘hygienic’ and ‘surgical’ hand disinfection. Rubbing 60 per cent... |
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SubjectTerms | Chlorhexidine - analogs & derivatives Chlorhexidine - pharmacology Detergents - pharmacology Escherichia coli - drug effects Hand - microbiology Hand Disinfection - methods Humans Povidone - analogs & derivatives Povidone-Iodine - pharmacology Staphylococcus aureus - drug effects Surface-Active Agents - pharmacology |
Title | Povidone-iodine and chlorhexidine gluconate-containing detergents for disinfection of hands |
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