The effect of p-aminosalicyclic acid on iron transport and assimilation in mycobacteria

• Published in: Biochimica et biophysica acta Vol. 385; no. 2; pp. 207 - 220
• Main Authors: Brown, Keith A., Ratledge, Colin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 07.04.1975
• Subjects: Aminobenzoates - metabolism; Aminosalicylic Acids - metabolism; Aminosalicylic Acids - pharmacology; Antimetabolites - pharmacology; Biological Transport; Cell-Free System; Growth Substances - biosynthesis; Iron - deficiency; Iron - metabolism; Mutation; Mycobacterium - drug effects; Mycobacterium - metabolism; Mycobacterium bovis - drug effects; Mycobacterium bovis - metabolism; Oxazoles - biosynthesis; Salicylates - metabolism

p-Aminosalicylic acid inhibits growth of Mycobacterium bovis BCG and Mycobacterium smegmatis more effectively if cells are growing with a sufficiency of iron (> 1 μg Fe/ml) in the medium than if cells are deficient in iron (<0.1 μg Fe/ml). In iron-deficient cultures formation of mycobactin, an...