Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model
Young cynomolgus monkeys, Macaca fascicularis, were chosen as a model to investigate the metabolism of 4-methylpyrazole and its interaction with methanol. Following a single dose of 4-methylpyrazole, the elimination of 4-methylpyrazole from the plasma followed a linear course; at a dose of 50 mg/kg...
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Published in | Archives of biochemistry and biophysics Vol. 199; no. 2; pp. 606 - 614 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.02.1980
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Abstract | Young cynomolgus monkeys,
Macaca fascicularis, were chosen as a model to investigate the metabolism of 4-methylpyrazole and its interaction with methanol. Following a single dose of 4-methylpyrazole, the elimination of 4-methylpyrazole from the plasma followed a linear course; at a dose of 50 mg/kg (424 μmol/kg) the constant rate of elimination of 4-methylpyrazole was approximately 13 μmol/kg/h with disappearance of the dose within 35 h. This rate of elimination was slower when the smaller dose of 20 mg 4-methylpyrazole was administered. The primary metabolite of 4-methylpyrazole, 4-hydroxymethylpyrazole, accumulated to levels at most 10% of those of 4-methylpyrazole and did not persist in the plasma after the elimination of 4-methylpyrazole. The concurrent administration of methanol with 4-methylpyrazole inhibited the disappearance of 4-methylpyrazole from the plasma about 25%, which suggested an interaction between the metabolism of the two compounds. As expected from its potent inhibitory effect on alcohol dehydrogenase, 4-methylpyrazole produced a profound and dose-dependent inhibition of the rate of elimination of methanol from the plasma. In addition, 4-methylpyrazole at a plasma level of greater than 10 μ
m was capable of preventing the accumulation of formic acid in methanol poisoned monkeys. In such a way 4-methylpyrazole repeatedly injected in various dose combinations was able to reverse methanol toxicity in the monkey. These studies indicated the usefulness of the monkey as a model to study 4-methylpyrazole activity and toxicity in light of its possible use to treat methanol poisoning in man. |
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AbstractList | Young cynomolgus monkeys,
Macaca fascicularis, were chosen as a model to investigate the metabolism of 4-methylpyrazole and its interaction with methanol. Following a single dose of 4-methylpyrazole, the elimination of 4-methylpyrazole from the plasma followed a linear course; at a dose of 50 mg/kg (424 μmol/kg) the constant rate of elimination of 4-methylpyrazole was approximately 13 μmol/kg/h with disappearance of the dose within 35 h. This rate of elimination was slower when the smaller dose of 20 mg 4-methylpyrazole was administered. The primary metabolite of 4-methylpyrazole, 4-hydroxymethylpyrazole, accumulated to levels at most 10% of those of 4-methylpyrazole and did not persist in the plasma after the elimination of 4-methylpyrazole. The concurrent administration of methanol with 4-methylpyrazole inhibited the disappearance of 4-methylpyrazole from the plasma about 25%, which suggested an interaction between the metabolism of the two compounds. As expected from its potent inhibitory effect on alcohol dehydrogenase, 4-methylpyrazole produced a profound and dose-dependent inhibition of the rate of elimination of methanol from the plasma. In addition, 4-methylpyrazole at a plasma level of greater than 10 μ
m was capable of preventing the accumulation of formic acid in methanol poisoned monkeys. In such a way 4-methylpyrazole repeatedly injected in various dose combinations was able to reverse methanol toxicity in the monkey. These studies indicated the usefulness of the monkey as a model to study 4-methylpyrazole activity and toxicity in light of its possible use to treat methanol poisoning in man. |
Author | Blomstrand, Rolf Östling-Wintzell, Helene Hedström, Karl-Göran McMartin, Kenneth E. Tolf, Bo-Ragnar |
Author_xml | – sequence: 1 givenname: Kenneth E. surname: McMartin fullname: McMartin, Kenneth E. organization: Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden – sequence: 2 givenname: Karl-Göran surname: Hedström fullname: Hedström, Karl-Göran organization: Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden – sequence: 3 givenname: Bo-Ragnar surname: Tolf fullname: Tolf, Bo-Ragnar organization: Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden – sequence: 4 givenname: Helene surname: Östling-Wintzell fullname: Östling-Wintzell, Helene organization: Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden – sequence: 5 givenname: Rolf surname: Blomstrand fullname: Blomstrand, Rolf organization: Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, Huddinge, Sweden |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6767446$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S0041-008X(78)80030-1 10.3891/acta.chem.scand.23-0255 10.1016/0006-2944(75)90122-2 10.1016/0024-3205(73)90185-9 10.1016/0024-3205(73)90186-0 10.1016/0006-291X(74)90581-6 10.1016/0041-008X(77)90175-2 10.1001/archopht.1977.04450100153022 10.1097/00005792-195312000-00002 10.1016/0041-008X(78)90040-6 10.1016/0024-3205(70)90214-6 10.1016/0006-2952(75)90087-8 10.1007/BF01897894 10.1111/j.1365-2362.1977.tb01640.x 10.1111/j.1600-0773.1976.tb03201.x 10.1159/000176142 10.1001/archopht.1977.04450100161023 10.1016/B978-0-12-107605-4.50012-3 10.1016/0002-9394(55)90010-6 10.1001/archopht.1977.04450100149021 10.1016/0041-008X(75)90174-X 10.3891/acta.chem.scand.23-0892 10.15288/qjsa.1968.29.449 10.1016/0003-9861(80)90317-3 10.1016/0026-0495(78)90001-X 10.1093/chromsci/7.5.312 10.1016/0006-291X(72)90042-3 10.1080/15287397509529315 10.1111/j.2042-7158.1972.tb09078.x 10.1007/BF01946169 10.1016/0006-2944(75)90172-6 10.1016/0006-2944(75)90171-4 10.1016/0006-2944(75)90147-7 |
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References | Björkhem, Blomstrand, Lantto, Svensson (BIB28) 1975; 12 Blomstrand (BIB24) 1972 Rydberg, Buijten, Neri (BIB32) 1972; 24 Protopopova, Klimenko, Skoldinov (BIB29) 1959; 4 Makar, Tephly (BIB3) 1975; 13 Tephly, Watkins, Goodman (BIB23) 1974; 5 Skladzinski, Beskid (BIB14) 1978; 16 Widmark (BIB33) 1930; Vol. 41 Watkins, Goodman, Tephly (BIB13) 1970; 6 Clay, Murphy (BIB20) 1977; 39 Lelbach (BIB15) 1969; 25 Baumbach, Cancilla, Martin-Amat, Tephly, McMartin, Makar, Hayreh, Hayreh (BIB27) 1977; 95 Lester, Keokosky, Felzenberg (BIB6) 1968; 29 Bennet, Cary, Mitchell, Cooper (BIB41) 1953; 32 Blomstrand, Löf, Östling (BIB36) 1977; 21 Martin-Amat, McMartin, Hayreh, Hayreh, Tephly (BIB40) 1978; 45 Dahlbom, Tolf, Åkeson, Lundquist, Theorell (BIB2) 1974; 57 Blomstrand, Ellin, Löf, Östling-Wintzell (BIB12) 1980; 199 Li, Theorell (BIB4) 1969; 23 Blomstrand, Theorell (BIB7) 1970; 9 Lieber, Rubin, DeCarli, Misra, Gang (BIB9) 1970; 22 Salaspuro, Lindros, Pikkarainen (BIB16) 1978; 27 Salaspuro, Pikkarainen, Lindros (BIB17) 1977; 7 Blomstrand, Löf, Östling (BIB37) 1977; Vol. III Blomstrand, Öhman (BIB38) 1973; 13 Martin-Amat, Tephly, McMartin, Makar, Hayreh, Hayreh, Baumbach, Cancilla (BIB25) 1977; 95 Hayreh, Mayreh, Baumbach, Cancilla, Martin-Amat, Tephly, McMartin, Makar (BIB26) 1977; 95 Theorell, Yonetani, Sjöberg (BIB1) 1969; 23 Magnusson, Nyberg, Bodin, Hansson (BIB10) 1972; 28 McDonald (BIB44) 1976; 39 McMartin, Makar, Martin-Amat, Palese, Tephly (BIB8) 1975; 13 Makar, McMartin, Palese, Tephly (BIB30) 1975; 13 Chou, Richardson (BIB19) 1978; 43 Clay, Murphy, Watkins (BIB22) 1975; 34 Blomstrand, Kager (BIB18) 1973; 13 Röe (BIB43) 1955; 7 Kager, Ericsson (BIB11) 1974; 82 Murphy, Watkins (BIB39) 1972; 49 Gilger, Potts (BIB35) 1955; 39 Pietruszko (BIB5) 1975; 24 McMartin, Martin-Amat, Makar, Tephly (BIB21) 1977; Vol. II Posner (BIB42) 1975; 1 Baker, Alenty, Zack (BIB31) 1969; 7 McMartin, Martin-Amat, Makar, Tephly (BIB34) 1977; 201 Martin-Amat (10.1016/0003-9861(80)90318-5_BIB25) 1977; 95 Blomstrand (10.1016/0003-9861(80)90318-5_BIB36) 1977; 21 Lieber (10.1016/0003-9861(80)90318-5_BIB9) 1970; 22 Lelbach (10.1016/0003-9861(80)90318-5_BIB15) 1969; 25 Widmark (10.1016/0003-9861(80)90318-5_BIB33) 1930; Vol. 41 Baumbach (10.1016/0003-9861(80)90318-5_BIB27) 1977; 95 Li (10.1016/0003-9861(80)90318-5_BIB4) 1969; 23 Blomstrand (10.1016/0003-9861(80)90318-5_BIB18) 1973; 13 Tephly (10.1016/0003-9861(80)90318-5_BIB23) 1974; 5 Pietruszko (10.1016/0003-9861(80)90318-5_BIB5) 1975; 24 Blomstrand (10.1016/0003-9861(80)90318-5_BIB24) 1972 Björkhem (10.1016/0003-9861(80)90318-5_BIB28) 1975; 12 Dahlbom (10.1016/0003-9861(80)90318-5_BIB2) 1974; 57 Blomstrand (10.1016/0003-9861(80)90318-5_BIB38) 1973; 13 Magnusson (10.1016/0003-9861(80)90318-5_BIB10) 1972; 28 Blomstrand (10.1016/0003-9861(80)90318-5_BIB37) 1977; Vol. III Gilger (10.1016/0003-9861(80)90318-5_BIB35) 1955; 39 Blomstrand (10.1016/0003-9861(80)90318-5_BIB12) 1980; 199 McMartin (10.1016/0003-9861(80)90318-5_BIB21) 1977; Vol. II Clay (10.1016/0003-9861(80)90318-5_BIB22) 1975; 34 Theorell (10.1016/0003-9861(80)90318-5_BIB1) 1969; 23 Skladzinski (10.1016/0003-9861(80)90318-5_BIB14) 1978; 16 Makar (10.1016/0003-9861(80)90318-5_BIB30) 1975; 13 Rydberg (10.1016/0003-9861(80)90318-5_BIB32) 1972; 24 Watkins (10.1016/0003-9861(80)90318-5_BIB13) 1970; 6 Baker (10.1016/0003-9861(80)90318-5_BIB31) 1969; 7 Makar (10.1016/0003-9861(80)90318-5_BIB3) 1975; 13 Röe (10.1016/0003-9861(80)90318-5_BIB43) 1955; 7 Posner (10.1016/0003-9861(80)90318-5_BIB42) 1975; 1 Protopopova (10.1016/0003-9861(80)90318-5_BIB29) 1959; 4 Bennet (10.1016/0003-9861(80)90318-5_BIB41) 1953; 32 Clay (10.1016/0003-9861(80)90318-5_BIB20) 1977; 39 McMartin (10.1016/0003-9861(80)90318-5_BIB8) 1975; 13 Kager (10.1016/0003-9861(80)90318-5_BIB11) 1974; 82 Salaspuro (10.1016/0003-9861(80)90318-5_BIB16) 1978; 27 Murphy (10.1016/0003-9861(80)90318-5_BIB39) 1972; 49 Chou (10.1016/0003-9861(80)90318-5_BIB19) 1978; 43 Hayreh (10.1016/0003-9861(80)90318-5_BIB26) 1977; 95 McMartin (10.1016/0003-9861(80)90318-5_BIB34) 1977; 201 Salaspuro (10.1016/0003-9861(80)90318-5_BIB17) 1977; 7 Blomstrand (10.1016/0003-9861(80)90318-5_BIB7) 1970; 9 Martin-Amat (10.1016/0003-9861(80)90318-5_BIB40) 1978; 45 Lester (10.1016/0003-9861(80)90318-5_BIB6) 1968; 29 McDonald (10.1016/0003-9861(80)90318-5_BIB44) 1976; 39 |
References_xml | – volume: 39 start-page: 39 year: 1977 end-page: 49 ident: BIB20 publication-title: Toxicol. Appl. Pharmacol contributor: fullname: Murphy – volume: Vol. III start-page: 427 year: 1977 end-page: 436 ident: BIB37 publication-title: Alcohol and Aldehyde Metabolizing Systems contributor: fullname: Östling – volume: 49 start-page: 283 year: 1972 end-page: 291 ident: BIB39 publication-title: Biochem. Biophys. Res. Commun contributor: fullname: Watkins – volume: 7 start-page: 399 year: 1955 end-page: 412 ident: BIB43 publication-title: Pharmacol. Rev contributor: fullname: Röe – volume: 13 start-page: 319 year: 1975 end-page: 333 ident: BIB8 publication-title: Biochem. Med contributor: fullname: Tephly – volume: 13 start-page: 117 year: 1975 end-page: 126 ident: BIB30 publication-title: Biochem. Med contributor: fullname: Tephly – volume: 39 start-page: 63 year: 1955 end-page: 86 ident: BIB35 publication-title: Amer. J. Ophthalmol contributor: fullname: Potts – volume: 4 start-page: 805 year: 1959 end-page: 810 ident: BIB29 publication-title: Chim. Nauka Prom contributor: fullname: Skoldinov – volume: 7 start-page: 312 year: 1969 end-page: 314 ident: BIB31 publication-title: J. Chromatogr. Sci contributor: fullname: Zack – volume: 45 start-page: 201 year: 1978 end-page: 208 ident: BIB40 publication-title: Toxicol. Appl. Pharmacol contributor: fullname: Tephly – volume: 95 start-page: 1851 year: 1977 end-page: 1858 ident: BIB26 publication-title: Arch. Ophthalmol contributor: fullname: Makar – volume: 9 start-page: 631 year: 1970 end-page: 640 ident: BIB7 publication-title: Life Sci contributor: fullname: Theorell – volume: 34 start-page: 49 year: 1975 end-page: 61 ident: BIB22 publication-title: Toxicol. Appl. Pharmacol contributor: fullname: Watkins – volume: 199 start-page: 591 year: 1980 end-page: 605 ident: BIB12 publication-title: Arch. Biochem. Biophys contributor: fullname: Östling-Wintzell – volume: 16 start-page: 13 year: 1978 end-page: 18 ident: BIB14 publication-title: Folia Histochem. Cytochem contributor: fullname: Beskid – start-page: 667 year: 1972 end-page: 679 ident: BIB24 publication-title: Structure and Function of Oxidation-Reduction Enzymes contributor: fullname: Blomstrand – volume: 24 start-page: 1603 year: 1975 end-page: 1607 ident: BIB5 publication-title: Biochem. Pharmacol contributor: fullname: Pietruszko – volume: Vol. II start-page: 419 year: 1977 end-page: 428 ident: BIB21 publication-title: Alcohol and Aldehyde Metabolizing Systems contributor: fullname: Tephly – volume: 13 start-page: 107 year: 1973 end-page: 112 ident: BIB38 publication-title: Life Sci contributor: fullname: Öhman – volume: 29 start-page: 449 year: 1968 end-page: 454 ident: BIB6 publication-title: Quart. J. Stud. Alc contributor: fullname: Felzenberg – volume: 95 start-page: 1859 year: 1977 end-page: 1865 ident: BIB27 publication-title: Arch. Ophthalmol contributor: fullname: Hayreh – volume: 23 start-page: 892 year: 1969 end-page: 902 ident: BIB4 publication-title: Acta Chem. Scand contributor: fullname: Theorell – volume: 1 start-page: 153 year: 1975 end-page: 171 ident: BIB42 publication-title: J. Toxicol. Environ. Health contributor: fullname: Posner – volume: 13 start-page: 113 year: 1973 end-page: 123 ident: BIB18 publication-title: Life Sci contributor: fullname: Kager – volume: 95 start-page: 1847 year: 1977 end-page: 1850 ident: BIB25 publication-title: Arch. Ophthalmol contributor: fullname: Cancilla – volume: 57 start-page: 549 year: 1974 end-page: 553 ident: BIB2 publication-title: Biochem. Biophys. Res. Commun contributor: fullname: Theorell – volume: 21 start-page: 148 year: 1977 end-page: 151 ident: BIB36 publication-title: Nutr. Metab contributor: fullname: Östling – volume: 201 start-page: 564 year: 1977 end-page: 572 ident: BIB34 publication-title: J. Pharmacol. Exp. Ther contributor: fullname: Tephly – volume: 23 start-page: 255 year: 1969 end-page: 260 ident: BIB1 publication-title: Acta. Chem. Scand contributor: fullname: Sjöberg – volume: 24 start-page: 651 year: 1972 end-page: 652 ident: BIB32 publication-title: J. Pharm. Pharmacol contributor: fullname: Neri – volume: 39 start-page: 513 year: 1976 end-page: 524 ident: BIB44 publication-title: Acta Pharmacol. Toxicol contributor: fullname: McDonald – volume: 43 start-page: 33 year: 1978 end-page: 44 ident: BIB19 publication-title: Toxicol. Appl. Pharmacol contributor: fullname: Richardson – volume: 28 start-page: 1198 year: 1972 end-page: 1200 ident: BIB10 publication-title: Experentia contributor: fullname: Hansson – volume: 82 start-page: 534 year: 1974 end-page: 538 ident: BIB11 publication-title: Acta Path. Microbiol. Scand contributor: fullname: Ericsson – volume: 25 start-page: 816 year: 1969 end-page: 818 ident: BIB15 publication-title: Experentia contributor: fullname: Lelbach – volume: 12 start-page: 205 year: 1975 end-page: 212 ident: BIB28 publication-title: Biochem. Med contributor: fullname: Svensson – volume: 32 start-page: 431 year: 1953 end-page: 463 ident: BIB41 publication-title: Medicine contributor: fullname: Cooper – volume: 6 start-page: 567 year: 1970 end-page: 572 ident: BIB13 publication-title: Mol. Pharmacol contributor: fullname: Tephly – volume: 5 start-page: 149 year: 1974 end-page: 177 ident: BIB23 publication-title: Essays in Toxicol contributor: fullname: Goodman – volume: 22 start-page: 615 year: 1970 end-page: 621 ident: BIB9 publication-title: Lab. Invest contributor: fullname: Gang – volume: 7 start-page: 487 year: 1977 end-page: 490 ident: BIB17 publication-title: Eur. J. Clin. Invest contributor: fullname: Lindros – volume: Vol. 41 year: 1930 ident: BIB33 publication-title: Kungl. Fysiografiska Sällskapets Handlingar, N.F. Bd contributor: fullname: Widmark – volume: 27 start-page: 631 year: 1978 end-page: 639 ident: BIB16 publication-title: Metabolism contributor: fullname: Pikkarainen – volume: 13 start-page: 334 year: 1975 end-page: 342 ident: BIB3 publication-title: Biochem. Med contributor: fullname: Tephly – volume: 43 start-page: 33 year: 1978 ident: 10.1016/0003-9861(80)90318-5_BIB19 publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/S0041-008X(78)80030-1 contributor: fullname: Chou – volume: 23 start-page: 255 year: 1969 ident: 10.1016/0003-9861(80)90318-5_BIB1 publication-title: Acta. Chem. Scand doi: 10.3891/acta.chem.scand.23-0255 contributor: fullname: Theorell – volume: 12 start-page: 205 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB28 publication-title: Biochem. Med doi: 10.1016/0006-2944(75)90122-2 contributor: fullname: Björkhem – start-page: 667 year: 1972 ident: 10.1016/0003-9861(80)90318-5_BIB24 contributor: fullname: Blomstrand – volume: 13 start-page: 107 year: 1973 ident: 10.1016/0003-9861(80)90318-5_BIB38 publication-title: Life Sci doi: 10.1016/0024-3205(73)90185-9 contributor: fullname: Blomstrand – volume: 13 start-page: 113 year: 1973 ident: 10.1016/0003-9861(80)90318-5_BIB18 publication-title: Life Sci doi: 10.1016/0024-3205(73)90186-0 contributor: fullname: Blomstrand – volume: 57 start-page: 549 year: 1974 ident: 10.1016/0003-9861(80)90318-5_BIB2 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/0006-291X(74)90581-6 contributor: fullname: Dahlbom – volume: 39 start-page: 39 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB20 publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/0041-008X(77)90175-2 contributor: fullname: Clay – volume: 201 start-page: 564 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB34 publication-title: J. Pharmacol. Exp. Ther contributor: fullname: McMartin – volume: 95 start-page: 1851 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB26 publication-title: Arch. Ophthalmol doi: 10.1001/archopht.1977.04450100153022 contributor: fullname: Hayreh – volume: 32 start-page: 431 year: 1953 ident: 10.1016/0003-9861(80)90318-5_BIB41 publication-title: Medicine doi: 10.1097/00005792-195312000-00002 contributor: fullname: Bennet – volume: 45 start-page: 201 year: 1978 ident: 10.1016/0003-9861(80)90318-5_BIB40 publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/0041-008X(78)90040-6 contributor: fullname: Martin-Amat – volume: 9 start-page: 631 year: 1970 ident: 10.1016/0003-9861(80)90318-5_BIB7 publication-title: Life Sci doi: 10.1016/0024-3205(70)90214-6 contributor: fullname: Blomstrand – volume: 24 start-page: 1603 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB5 publication-title: Biochem. Pharmacol doi: 10.1016/0006-2952(75)90087-8 contributor: fullname: Pietruszko – volume: 25 start-page: 816 year: 1969 ident: 10.1016/0003-9861(80)90318-5_BIB15 publication-title: Experentia doi: 10.1007/BF01897894 contributor: fullname: Lelbach – volume: 4 start-page: 805 year: 1959 ident: 10.1016/0003-9861(80)90318-5_BIB29 publication-title: Chim. Nauka Prom contributor: fullname: Protopopova – volume: Vol. III start-page: 427 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB37 contributor: fullname: Blomstrand – volume: 7 start-page: 487 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB17 publication-title: Eur. J. Clin. Invest doi: 10.1111/j.1365-2362.1977.tb01640.x contributor: fullname: Salaspuro – volume: 39 start-page: 513 year: 1976 ident: 10.1016/0003-9861(80)90318-5_BIB44 publication-title: Acta Pharmacol. Toxicol doi: 10.1111/j.1600-0773.1976.tb03201.x contributor: fullname: McDonald – volume: 21 start-page: 148 issue: Suppl. 1 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB36 publication-title: Nutr. Metab doi: 10.1159/000176142 contributor: fullname: Blomstrand – volume: 95 start-page: 1859 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB27 publication-title: Arch. Ophthalmol doi: 10.1001/archopht.1977.04450100161023 contributor: fullname: Baumbach – volume: 7 start-page: 399 year: 1955 ident: 10.1016/0003-9861(80)90318-5_BIB43 publication-title: Pharmacol. Rev contributor: fullname: Röe – volume: 5 start-page: 149 year: 1974 ident: 10.1016/0003-9861(80)90318-5_BIB23 publication-title: Essays in Toxicol doi: 10.1016/B978-0-12-107605-4.50012-3 contributor: fullname: Tephly – volume: 16 start-page: 13 year: 1978 ident: 10.1016/0003-9861(80)90318-5_BIB14 publication-title: Folia Histochem. Cytochem contributor: fullname: Skladzinski – volume: 39 start-page: 63 year: 1955 ident: 10.1016/0003-9861(80)90318-5_BIB35 publication-title: Amer. J. Ophthalmol doi: 10.1016/0002-9394(55)90010-6 contributor: fullname: Gilger – volume: 95 start-page: 1847 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB25 publication-title: Arch. Ophthalmol doi: 10.1001/archopht.1977.04450100149021 contributor: fullname: Martin-Amat – volume: 34 start-page: 49 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB22 publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/0041-008X(75)90174-X contributor: fullname: Clay – volume: 23 start-page: 892 year: 1969 ident: 10.1016/0003-9861(80)90318-5_BIB4 publication-title: Acta Chem. Scand doi: 10.3891/acta.chem.scand.23-0892 contributor: fullname: Li – volume: 29 start-page: 449 year: 1968 ident: 10.1016/0003-9861(80)90318-5_BIB6 publication-title: Quart. J. Stud. Alc doi: 10.15288/qjsa.1968.29.449 contributor: fullname: Lester – volume: 6 start-page: 567 year: 1970 ident: 10.1016/0003-9861(80)90318-5_BIB13 publication-title: Mol. Pharmacol contributor: fullname: Watkins – volume: 199 start-page: 591 year: 1980 ident: 10.1016/0003-9861(80)90318-5_BIB12 publication-title: Arch. Biochem. Biophys doi: 10.1016/0003-9861(80)90317-3 contributor: fullname: Blomstrand – volume: 27 start-page: 631 year: 1978 ident: 10.1016/0003-9861(80)90318-5_BIB16 publication-title: Metabolism doi: 10.1016/0026-0495(78)90001-X contributor: fullname: Salaspuro – volume: 7 start-page: 312 year: 1969 ident: 10.1016/0003-9861(80)90318-5_BIB31 publication-title: J. Chromatogr. Sci doi: 10.1093/chromsci/7.5.312 contributor: fullname: Baker – volume: 49 start-page: 283 year: 1972 ident: 10.1016/0003-9861(80)90318-5_BIB39 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/0006-291X(72)90042-3 contributor: fullname: Murphy – volume: 1 start-page: 153 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB42 publication-title: J. Toxicol. Environ. Health doi: 10.1080/15287397509529315 contributor: fullname: Posner – volume: 24 start-page: 651 year: 1972 ident: 10.1016/0003-9861(80)90318-5_BIB32 publication-title: J. Pharm. Pharmacol doi: 10.1111/j.2042-7158.1972.tb09078.x contributor: fullname: Rydberg – volume: Vol. II start-page: 419 year: 1977 ident: 10.1016/0003-9861(80)90318-5_BIB21 contributor: fullname: McMartin – volume: 22 start-page: 615 year: 1970 ident: 10.1016/0003-9861(80)90318-5_BIB9 publication-title: Lab. Invest contributor: fullname: Lieber – volume: 28 start-page: 1198 year: 1972 ident: 10.1016/0003-9861(80)90318-5_BIB10 publication-title: Experentia doi: 10.1007/BF01946169 contributor: fullname: Magnusson – volume: 82 start-page: 534 year: 1974 ident: 10.1016/0003-9861(80)90318-5_BIB11 publication-title: Acta Path. Microbiol. Scand contributor: fullname: Kager – volume: 13 start-page: 334 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB3 publication-title: Biochem. Med doi: 10.1016/0006-2944(75)90172-6 contributor: fullname: Makar – volume: 13 start-page: 319 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB8 publication-title: Biochem. Med doi: 10.1016/0006-2944(75)90171-4 contributor: fullname: McMartin – volume: 13 start-page: 117 year: 1975 ident: 10.1016/0003-9861(80)90318-5_BIB30 publication-title: Biochem. Med doi: 10.1016/0006-2944(75)90147-7 contributor: fullname: Makar – volume: Vol. 41 year: 1930 ident: 10.1016/0003-9861(80)90318-5_BIB33 contributor: fullname: Widmark |
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Macaca fascicularis, were chosen as a model to investigate the metabolism of 4-methylpyrazole and its interaction with methanol.... |
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SubjectTerms | Alcohol Oxidoreductases - antagonists & inhibitors Animals Disease Models, Animal Dose-Response Relationship, Drug Haplorhini Liver - enzymology Macaca - metabolism Macaca fascicularis - metabolism Methanol - metabolism Methanol - poisoning Pyrazoles - metabolism Pyrazoles - therapeutic use Pyrazoles - toxicity |
Title | Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model |
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