3,7-Diazabicyclo[3.3.1]nonanes and 1,3-diazaadamantanes containing monoterpenoid moieties as synthetic adaptogens: synthesis, ADMET predictions, and in vivo biological activity - Kotliarova, Anastasiia A.; Ponomarev, Konstantin Yu; Morozova, Ekaterina A.; Suslov, Evgeniy V.; Pavlova, Alla V.; Tolstikova, Tatyana G.; Volcho, Konstantin P.; Salakhutdinov, Nariman F. (Medicinal chemistry research, 2025)
Keywords: Acute toxicity; Adaptogens; Biochemistry; Biocompatibility; Biological activity; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Blood-brain barrier; Fatigue; Fatigue tests; Gastrointestinal system; Gastrointestinal tract; In vivo methods and tests; Inorganic Chemistry; Medicinal Chemistry; Nonanes; Original Research Article; Pharmacology; Pharmacology/Toxicology; Safety margins; Structure-activity relationships; Toxicity testing; Synthetic adaptogens; Monoterpene; Bispidine; SwissADME, PreADMET; Structure-activity relationship