N-(3-[ 18F]fluoropropyl)-spiperone: The preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

• Published in: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Vol. 15; no. 1; pp. 83,95 - 93,97
• Main Authors: Welch, M.J., Katzenellenbogen, J.A., Mathias, C.J., Brodack, J.W., Carlson, K.E., Chi, D.Y., Dence, C.S., Kilbourn, M.R., Perlmutter, J.S., Raichle, M.E., Ter-Pogossian, M.M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 1988
• Subjects: Animals; Blood-Brain Barrier; Brain - diagnostic imaging; Brain - metabolism; Female; Humans; Papio; Rats; Rats, Inbred Strains; Receptors, Dopamine - analysis; Spiperone - analogs & derivatives; Spiperone - pharmacokinetics; Tomography, Emission-Computed

The ligands currently used for PET studies of the dopamine receptor are fluorine-18-labeled spiperone (FSp) and carbon-11 or fluorine-18-labeled N-methyl-spiperone. All three of these ligands have drawbacks in either their chemical preparation or their biological behavior. We have previously prepare...