Experiment and Computational Study on Pd-Catalyzed MIA-Directed Ortho-C-H Alkynlation of Phenylalanine

• Published in: Asian journal of organic chemistry Vol. 13; no. 7
• Main Authors: Zhang, Fujie, Liang, Yu, Liu, Dong-Hui, Liu, Peng-Yu, Huang, Liangliang, He, Yu-Peng, Yu, Fang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.07.2024
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; C-H activation; MIA; 1,5-ENYNES; 2+2+2 CYCLOADDITION; alkynlation; ALKYNYLATION; SELECTIVITY; CYCLIZATION; AMIDES

The direct ortho-alkynylation of substituted phenylalanine has been successfully achieved through methoxyiminoacyl (MIA)-mediated Pd-catalyzed C-H functionalization. This innovative protocol showcases the ability to apply a diverse range of phenylalanine substrates, resulting in the efficient synthe...