One‐Step Fabrication of Highly Customizable Porous Core–Shell Microspheres for the Construction of a 3D Physiologically Relevant Perivascular‐Endosteal Multi‐Microenvironment Model of Breast Cancer Bone Metastasis

• Published in: Advanced functional materials Vol. 35; no. 20
• Main Authors: Hong, Meiying, Wang, Guanxiong, Yang, Menghan, Liu, Hong, Huang, Haisen, Liu, Tiantian, Wang, Siping, Shen, Rui, He, Huatao, Li, Yi, Du, Ting, Hao, Xin, Xie, Qingyun, Shen, Chongyang, Wang, Yaolei
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.05.2025
• Subjects: Alkaline phosphatase; aqueous two‐phase emulsions; Biological activity; Breast cancer; breast cancer bone metastasis; Chemical composition; endosteal microenvironment; in vitro 3D cell culture; Localization; Metastasis; Microspheres; perivascular microenvironment; porous core‐shell microspheres; Three dimensional models; vascularization

The 3D model of the perivascular‐endosteal multi‐microenvironment (PVM‐EM) is crucial for studying early stage breast cancer (BrCa) bone metastasis. However, existing models struggle to accurately represent the composition and spatial intricacies of multi‐microenvironments, limiting their ability to...