Neur1 and Neur2 are required for hippocampus‐dependent spatial memory and synaptic plasticity

• Published in: Hippocampus Vol. 30; no. 11; pp. 1158 - 1166
• Main Authors: Lee, Jaehyun, Yoon, Ki‐Jun, Park, Pojeong, Lee, Chaery, Kim, Min Jung, Han, Dae Hee, Kim, Ji‐il, Kim, Somi, Lee, Hye‐Ryeon, Lee, Yeseul, Jang, Eun‐Hae, Ko, Hyoung‐Gon, Kong, Young‐Yun, Kaang, Bong‐Kiun
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020; Wiley Subscription Services, Inc
• Subjects: E3 ligase; Hippocampus; hippocampus‐dependent learning and memory; Homology; long‐term potentiation; Neur1; Neur2; Potentiation; Protein biosynthesis; Spatial memory; Synaptic plasticity; Ubiquitin; Ubiquitin-protein ligase; ubiquitination; E3 ligase; Neur2; ubiquitination; hippocampus-dependent learning and memory; spatial memory; Neur1; synaptic plasticity; long-term potentiation

Neur1 and Neur2, mouse homologs of the Drosophila neur gene, consist of two neuralized homology repeat domains and a RING domain. Both Neur1 and Neur2 are expressed in the whole adult brain and encode E3 ubiquitin ligases, which play a crucial role in the Notch signaling pathways. A previous study r...