Starvation-induced secretory changes of insulin, somatostatin, and glucagon and their modification by 2-bromostearate

• Published in: Hormone and metabolic research Vol. 16; no. 3; p. 115
• Main Authors: Tamarit-Rodriguez, J, Vara, E, Tamarit, J
• Format: Journal Article
• Language: English
• Published: Germany 01.03.1984
• Subjects: Animals; Glucagon - metabolism; Glucose - pharmacology; Insulin - metabolism; Insulin Secretion; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; Male; Palmitates - pharmacology; Rats; Rats, Inbred Strains; Somatostatin - metabolism; Starvation - metabolism; Stearic Acids - pharmacology

The hypothesis was made of an increased oxidation of fatty acids (FFA) and a decrease of their esterification rate contributing to the islet secretory defect during starvation. 2-Bromostearate (BrS), a FFA-oxidation inhibitor, was therefore tested on the islet secretion of insulin, glucagon and soma...