Expression of transforming growth factor alpha in the liver before and after interferon alfa therapy for chronic hepatitis B

• Published in: Hepatology (Baltimore, Md.) Vol. 22; no. 4 Pt 1; p. 1021
• Main Authors: Morimitsu, Y, Kleiner, Jr, D E, Conjeevaram, H S, Hsia, C C, Di Bisceglie, A M, Tabor, E
• Format: Journal Article
• Language: English
• Published: United States 01.10.1995
• Subjects: Adult; Alanine Transaminase - blood; Antiviral Agents - therapeutic use; Female; Hepatitis B - metabolism; Hepatitis B - pathology; Hepatitis B - therapy; Hepatitis B - virology; Hepatitis B Surface Antigens - analysis; Humans; Immunohistochemistry; Interferon Type I - therapeutic use; Liver - metabolism; Liver - pathology; Liver - virology; Male; Middle Aged; Recombinant Proteins; Transforming Growth Factor alpha - metabolism

The effect of interferon alfa (IFN-alpha) therapy on the expression of transforming growth factor alpha (TGF-alpha) in the liver during chronic hepatitis B was investigated. Serial liver biopsy specimens were evaluated from 35 patients who had participated in a randomized, controlled trial of recomb...