Palladium‐Catalyzed Construction of Phthalides Bearing Two Adjacent Stereocenters through Retro‐oxa‐Michael Addition

• Published in: Chinese journal of chemistry Vol. 42; no. 23; pp. 3006 - 3012
• Main Authors: Liu, Li‐Xia, Niu, Tong, Bai, Yu‐Qing, Zhou, Yong‐Gui
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.12.2024; Wiley; Wiley Subscription Services, Inc
• Subjects: Alkylation; Asymmetric allylic alkylation; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Chemoselectivity; Dynamic kinetic resolution; Lactones; Optical activity; Palladium; Palladium catalysis; Physical Sciences; Retro‐oxa‐Michael addition; Science & Technology; Stereochemistry; Stereoselectivity; Asymmetric allylic alkylation; ASYMMETRIC TRANSFER HYDROGENATION; CARBONATES; Chemoselectivity; ALLYLATION; Dynamic kinetic resolution; Stereochemistry; ALKYLATIONS; TERTIARY; Retro-oxa-Michael addition; Lactones; KETONES; DIPHOSPHINE LIGANDS; Palladium catalysis; ALLYLIC SUBSTITUTION

Comprehensive Summary Optically active phthalides are prevalent in many natural and bioactive products. Herein, a novel dynamic kinetic resolution of isobenzofuranone derivatives through palladium‐catalyzed asymmetric allylic alkylation has been developed to synthesize phthalide derivatives bearing...