Intracoronary Cytoprotective Gene Therapy

• Published in: Journal of the American College of Cardiology Vol. 66; no. 2; pp. 139 - 153
• Main Authors: Woitek, Felix, MD, Zentilin, Lorena, PhD, Hoffman, Nicholas E., PhD, Powers, Jeffery C., BS, Ottiger, Isabel, BA, Parikh, Suraj, BS, Kulczycki, Anna M., BS, Hurst, Marykathryn, MS, Ring, Nadja, BS, Wang, Tao, MD, PhD, Shaikh, Farah, MD, Gross, Polina, BS, Singh, Harinder, PhD, Kolpakov, Mikhail A., MD, PhD, Linke, Axel, MD, Houser, Steven R., PhD, Rizzo, Victor, PhD, Sabri, Abdelkarim, PhD, Madesh, Muniswamy, PhD, Giacca, Mauro, MD, PhD, Recchia, Fabio A., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 14.07.2015; Elsevier Limited
• Subjects: Adenosine; Cardiology; Cardiomyocytes; Cardiomyopathy; Cardiovascular; Cardiovascular disease; Coronary vessels; Cytomegalovirus; Dogs; Enzymes; Experiments; Gene therapy; heart failure; Internal Medicine; Laboratory animals; Ligands; Statistical analysis; Studies; translational approach; Variance analysis; Vascular endothelial growth factor; Vectors (Biology); LV; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2; GFP; LVEDP; cytomegalovirus; left ventricular; dilated cardiomyopathy; heart failure; VEGF; gene therapy; left ventricular end-diastolic pressure; CMV; green fluorescent protein; DCM; adeno-associated virus serotype 9; atrial natriuretic factor/protein; AAV; vascular endothelial growth factor; VEGFR-2; VEGFR-1; translational approach; ANF; nicotinamide adenine dinucleotide phosphate oxidase; HF; NOX2

Abstract Background Vascular endothelial growth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic mechanisms via VEGF receptors. Therefore, VEGF-B might be an ideal candidate for the treatment of dilated cardiomyopathy, which displays modest microvascular rarefaction an...