Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system

• Published in: Oncotarget Vol. 9; no. 27; pp. 18832 - 18843
• Main Authors: Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C M, Jacobs, Heinz
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 10.04.2018
• Subjects: Research Paper; precision cancer medicine; DNA damage tolerance; cancer target; cisplatin; chemotherapy

DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink repair. In this way DDT minimizes replication stress inflicted by a wide range of endogenous and exogenous agents, and provides a critical first li...