Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease

• Published in: Nanomedicine Vol. 51; p. 102689
• Main Authors: Fonseca-Santos, Bruno, Cazarin, Camila André, da Silva, Patrícia Bento, dos Santos, Kaio Pini, da Rocha, Márcia Cristina Oliveira, Báo, Sônia Nair, De-Souza, Márcia Maria, Chorilli, Marlus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2023
• Subjects: Administration, Intranasal; Alzheimer Disease - drug therapy; Animals; Brain; Colloids; Liquid Crystals - chemistry; Microemulsion; Neuroinflammatory Diseases; Neurological disease; Polyoxyethylene oleyl ether; Resveratrol - pharmacology; Resveratrol - therapeutic use; Scattering, Small Angle; X-Ray Diffraction; Brain; Neurological disease; Microemulsion; Polyoxyethylene oleyl ether; Colloids

Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and d...