The presence of PD-1 positive tumor infiltrating lymphocytes in triple negative breast cancers is associated with a favorable outcome of disease

• Published in: Oncotarget Vol. 9; no. 5; pp. 6201 - 6212
• Main Authors: Brockhoff, Gero, Seitz, Stephan, Weber, Florian, Zeman, Florian, Klinkhammer-Schalke, Monika, Ortmann, Olaf, Wege, Anja Kathrin
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 19.01.2018
• Subjects: Research Paper; PD-(L)1; triple negative breast cancer (TNBC)

Triple negative breast cancer patients have a poor course of disease not least because of limited treatment options however immunotherapy by targeting the PD-1/PD-L1 checkpoint system is a promising strategy to improve the outcome. Here we systematically investigated the expression of PD-1 on tumor...