ROC analysis of p16 expression in cell blocks of metastatic head and neck squamous cell carcinoma

• Published in: Journal of the American Society of Cytopathology JASC Vol. 10; no. 4; pp. 423 - 428
• Main Authors: Wilson, Bennett L., Israel, Anna-Karoline, Ettel, Mark G., Lott Limbach, Abberly A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2021
• Subjects: Alphapapillomavirus - metabolism; Biomarkers, Tumor - metabolism; Biopsy, Fine-Needle - methods; Carcinoma; Cell block; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cytology; Female; Fine-needle aspiration; Human papillomavirus; Humans; Immunohistochemistry - methods; In Situ Hybridization - methods; Lymph Nodes - pathology; Lymphatic Metastasis - diagnosis; Lymphatic Metastasis - pathology; Male; Middle Aged; Neck; Oropharyngeal cancer; Oropharyngeal Neoplasms - diagnosis; Oropharyngeal Neoplasms - metabolism; Oropharyngeal Neoplasms - pathology; Oropharyngeal Neoplasms - virology; p16; Papillomavirus Infections - diagnosis; Papillomavirus Infections - metabolism; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; RNA, Viral - metabolism; ROC Curve; Sensitivity and Specificity; Squamous cell; Squamous Cell Carcinoma of Head and Neck - diagnosis; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - virology; Human papillomavirus; Fine-needle aspiration; Carcinoma; Cell block; Squamous cell; p16; Oropharyngeal cancer; Cytology

Oropharyngeal squamous cell carcinoma is associated with human papillomavirus (HPV) and often presents with early metastasis to cervical neck lymph nodes that are amenable to fine-needle aspiration (FNA). The most common method of HPV status determination is p16 immunohistochemistry (IHC). The liter...