Associated factors in modulating aflatoxin B1-albumin adduct level in three Chinese populations
To elucidate the potential factors modulating exposure to aflatoxin B1 (AFB1) in three Chinese populations, an epidemiologic study was conducted in Fusui County and Nanning City of Guangxi Province and Chengdu City of Sichuan Province. The incidence rates of hepatocelluar carcinoma (HCC) for males i...
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Published in | Digestive diseases and sciences Vol. 50; no. 3; pp. 525 - 532 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.03.2005
Springer Nature B.V |
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Abstract | To elucidate the potential factors modulating exposure to aflatoxin B1 (AFB1) in three Chinese populations, an epidemiologic study was conducted in Fusui County and Nanning City of Guangxi Province and Chengdu City of Sichuan Province. The incidence rates of hepatocelluar carcinoma (HCC) for males in these three regions were 92-97 per 100,000, 32-47 per 100,000, and 21 per 100,000, respectively. Eighty-nine residents from Fusui, 196 residents from Nanning, and 118 residents from Chengdu were screened for AFB1-albumin adduct (AAA) levels and hepatitis virus (HBV, HCV, HDV, HEV, and HGV) infections, as well as liver biochemistry (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], y-glutamyl transpeptidase [GGT], 5'-nucleotidase, globulin [GLO], direct bilirubin, indirect bilirubin, and bile acid levels). At least one marker of hepatitis virus (HV) infection was present in 47.2% (42/89) of subjects from Fusui, while in Nanning and Chengdu the values were 15.8% (31/196) and 22.0% (26/118), respectively. In contrast to females, a higher level of AAA was observed in males; the difference was statistically significant in both the Nanning (P = 0.023) and the Chengdu (P = 0.026) subjects. In the Chengdu group, there was a significantly higher level of AAA in cases with HV infection (P = 0.041). There was a close association between AAA level and BMI in the adults without HV infection (r = 0.148, P = 0.044). Also, AAA was closely associated with DBIL and GGT in non-HV-infected minors (P < 0.05), closely associated with ALB, GLO, and GGT in HV-infected minors (P < 0.05), and closely associated with IBIL, GLO, TBA, and AST in non-HV-infected adults (P < 0.01). The co-effect of HV infection and AFB1 exposure may be responsible for the high risk of HCC in the Fusui region, whereas age, gender, BMI, and HV infection may modify individual aflatoxin levels. The relationship between AAA level and liver biochemistry indicates injury induced by aflatoxin to both hepatic parenchyma and biliary tract. But the associations vary with age and HV infection status. |
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AbstractList | To elucidate the potential factors modulating exposure to aflatoxin B1 (AFB1) in three Chinese populations, an epidemiologic study was conducted in Fusui County and Nanning City of Guangxi Province and Chengdu City of Sichuan Province. The incidence rates of hepatocelluar carcinoma (HCC) for males in these three regions were 92-97 per 100,000, 32-47 per 100,000, and 21 per 100,000, respectively. Eighty-nine residents from Fusui, 196 residents from Nanning, and 118 residents from Chengdu were screened for AFB1-albumin adduct (AAA) levels and hepatitis virus (HBV, HCV, HDV, HEV, and HGV) infections, as well as liver biochemistry (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], y-glutamyl transpeptidase [GGT], 5'-nucleotidase, globulin [GLO], direct bilirubin, indirect bilirubin, and bile acid levels). At least one marker of hepatitis virus (HV) infection was present in 47.2% (42/89) of subjects from Fusui, while in Nanning and Chengdu the values were 15.8% (31/196) and 22.0% (26/118), respectively. In contrast to females, a higher level of AAA was observed in males; the difference was statistically significant in both the Nanning (P = 0.023) and the Chengdu (P = 0.026) subjects. In the Chengdu group, there was a significantly higher level of AAA in cases with HV infection (P = 0.041). There was a close association between AAA level and BMI in the adults without HV infection (r = 0.148, P = 0.044). Also, AAA was closely associated with DBIL and GGT in non-HV-infected minors (P < 0.05), closely associated with ALB, GLO, and GGT in HV-infected minors (P < 0.05), and closely associated with IBIL, GLO, TBA, and AST in non-HV-infected adults (P < 0.01). The co-effect of HV infection and AFB1 exposure may be responsible for the high risk of HCC in the Fusui region, whereas age, gender, BMI, and HV infection may modify individual aflatoxin levels. The relationship between AAA level and liver biochemistry indicates injury induced by aflatoxin to both hepatic parenchyma and biliary tract. But the associations vary with age and HV infection status. To elucidate the potential factors modulating exposure to aflatoxin B1 (AFB1) in three Chinese populations, an epidemiologic study was conducted in Fusui County and Nanning City of Guangxi Province and Chengdu City of Sichuan Province. The incidence rates of hepatocelluar carcinoma (HCC) for males in these three regions were 92-97 per 100,000, 32-47 per 100,000, and 21 per 100,000, respectively. Eighty-nine residents from Fusui, 196 residents from Nanning, and 118 residents from Chengdu were screened for AFB 1-albumin adduct (AAA) levels and hepatitis virus (HBV, HCV, HDV, HEV, and HGV) infections, as well as liver biochemistry (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], γ-glutamyl transpeptidase [GGT], 5[variant prime]-nucleotidase, globulin [GLO], direct bilirubin, indirect bilirubin, and bile acid levels). At least one marker of hepatitis virus (HV) infection was present in 47.2% (42/89) of subjects from Fusui, while in Nanning and Chengdu the values were 15.8% (31/196) and 22.0% (26/118), respectively. In contrast to females, a higher level of AAA was observed in males; the difference was statistically significant in both the Nanning ( P = 0.023) and the Chengdu (P = 0.026) subjects. In the Chengdu group, there was a significantly higher level of AAA in cases with HV infection (P = 0.041). There was a close association between AAA level and BMI in the adults without HV infection (r = 0.148, P = 0.044). Also, AAA was closely associated with DBIL and GGT in non-HV-infected minors (P < 0.05), closely associated with ALB, GLO, and GGT in HV-infected minors (P < 0.05), and closely associated with IBIL, GLO, TBA, and AST in non-HV-infected adults (P < 0.01). The co-effect of HV infection and AFB1 exposure may be responsible for the high risk of HCC in the Fusui region, whereas age, gender, BMI, and HV infection may modify individual aflatoxin levels. The relationship between AAA level and liver biochemistry indicates injury induced by aflatoxin to both hepatic parenchyma and biliary tract. But the associations vary with age and HV infection status. |
Author | LIU, Tang-Wei PENG, Min-Hao SANTELLA, Regina M YAN, Lu-Nam WANG, Lian-Wen WANG QIAO LI, Le-Qun LIANG, Ren-Xiang PENG TAO WET, Zong-Liang ONG, Choon-Nam LIU, Zhi-Ming SHEN, Han-Ming QIN XUE |
Author_xml | – sequence: 1 surname: PENG TAO fullname: PENG TAO organization: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China – sequence: 2 givenname: Zhi-Ming surname: LIU fullname: LIU, Zhi-Ming organization: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China – sequence: 3 surname: WANG QIAO fullname: WANG QIAO organization: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States – sequence: 4 givenname: Han-Ming surname: SHEN fullname: SHEN, Han-Ming organization: Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China – sequence: 5 givenname: Choon-Nam surname: ONG fullname: ONG, Choon-Nam organization: Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China – sequence: 6 givenname: Regina M surname: SANTELLA fullname: SANTELLA, Regina M organization: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States – sequence: 7 givenname: Tang-Wei surname: LIU fullname: LIU, Tang-Wei organization: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China – sequence: 8 givenname: Le-Qun surname: LI fullname: LI, Le-Qun organization: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China – sequence: 9 givenname: Min-Hao surname: PENG fullname: PENG, Min-Hao organization: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China – sequence: 10 surname: QIN XUE fullname: QIN XUE organization: Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China – sequence: 11 givenname: Lu-Nam surname: YAN fullname: YAN, Lu-Nam organization: Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China – sequence: 12 givenname: Ren-Xiang surname: LIANG fullname: LIANG, Ren-Xiang organization: Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China – sequence: 13 givenname: Zong-Liang surname: WET fullname: WET, Zong-Liang organization: Department of General Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, China – sequence: 14 givenname: Lian-Wen surname: WANG fullname: WANG, Lian-Wen organization: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, United States |
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CitedBy_id | crossref_primary_10_18632_oncotarget_17660 crossref_primary_10_3920_WMJ2014_1761 crossref_primary_10_1371_journal_pone_0248037 crossref_primary_10_1016_j_canlet_2008_01_006 crossref_primary_10_1186_s12935_015_0223_z crossref_primary_10_1038_srep24558 crossref_primary_10_3892_mmr_2013_1558 crossref_primary_10_1186_1758_2652_14_53 crossref_primary_10_3390_toxins12090591 crossref_primary_10_1016_j_ijheh_2013_08_007 crossref_primary_10_1080_02652030701598694 crossref_primary_10_3390_toxins13100678 crossref_primary_10_1002_jcla_23310 crossref_primary_10_3390_toxins15110646 crossref_primary_10_1080_19440049_2011_581698 crossref_primary_10_1111_j_1349_7006_2006_00380_x |
Cites_doi | 10.1207/S15327914NC382_6 10.1016/0005-2736(88)90131-9 10.1007/s007740050081 10.1038/sj.bjc.6600584 10.1046/j.1365-3156.2000.00664.x 10.1016/0300-483X(89)90076-0 10.1046/j.1365-2710.1999.00246.x 10.7589/0090-3558-33.1.112 10.1093/toxsci/55.2.444 10.1093/carcin/8.6.819 10.1081/PFC-120018449 10.1289/ehp.01109833 10.1093/carcin/10.6.1099 10.1016/0035-9203(92)90253-9 10.1080/02724936.1995.11747757 10.1002/hep.510240108 10.1093/carcin/9.7.1323 10.1002/(SICI)1097-0215(20000401)86:1<1::AID-IJC1>3.0.CO;2-I 10.1016/0923-2508(96)84713-9 10.1002/hep.510290441 10.1016/0378-4274(87)90210-4 10.1079/BJN19910068 |
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Keywords | hepatitis virus Albumin Hepatic disease Hepatocellular carcinoma Malignant tumor AFB1-albumin adducts Virus Toxin Hepatitis Risk factor Aflatoxin B1 Digestive diseases Chinese |
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Snippet | To elucidate the potential factors modulating exposure to aflatoxin B1 (AFB1) in three Chinese populations, an epidemiologic study was conducted in Fusui... |
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SubjectTerms | Aflatoxin B1 - blood Aflatoxin B1 - metabolism Aflatoxins - blood Aflatoxins - metabolism Age Distribution Albumins - metabolism Analysis of Variance Biological and medical sciences Biomarkers - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - epidemiology Chi-Square Distribution China - epidemiology Cohort Studies Endemic Diseases - statistics & numerical data Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis, Viral, Human - blood Hepatitis, Viral, Human - epidemiology Hepatitis, Viral, Human - virology Humans Incidence Linear Models Liver Neoplasms - diagnosis Liver Neoplasms - epidemiology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Probability Registries Severity of Illness Index Sex Distribution Tumors |
Title | Associated factors in modulating aflatoxin B1-albumin adduct level in three Chinese populations |
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