Detection of alkylating agents by the analysis of amino acid residues in hemoglobin and urine 1. The in vivo and in vitro effects of ethyl methanesulfonate, methyl methanesulfonate, hycanthone methanesulfonate, and naltrexone

• Published in: Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 54; no. 3; pp. 271 - 281
• Main Authors: Truong, Lan, Ward, Jonathan B., Legator, Marvin S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.1978
• Subjects: Alkylating Agents - pharmacology; Amino Acid Sequence; Amino Acids - analysis; Amino Acids - urine; Animals; Ethyl Methanesulfonate - pharmacology; Hemoglobins - metabolism; Histidine - metabolism; Humans; Hycanthone - pharmacology; Male; Methyl Methanesulfonate - pharmacology; Naltrexone - pharmacology; Phenylalanine - metabolism; Proline - metabolism; Rats; PBS; MMS; RBC; EMS

The effect of alkylating agents on the amino acid composition of rat and human hemoglobin has been examined. Because the amino acid compositions of these proteins are well established, the changes in the molar ratios of specific amino acids could be monitored in purified hemoglobin samples. Ratios o...