Human muscle precursor cell regeneration in the mouse host is enhanced by growth factors

• Published in: Human gene therapy Vol. 15; no. 11; p. 1109
• Main Authors: Brimah, K, Ehrhardt, J, Mouly, V, Butler-Browne, G S, Partridge, T A, Morgan, J E
• Format: Journal Article
• Language: English
• Published: United States 01.11.2004
• Subjects: Animals; Cell Transplantation - methods; Fibroblast Growth Factor 2 - metabolism; Growth Substances - metabolism; Humans; Insulin-Like Growth Factor I - metabolism; Lamin Type A - biosynthesis; Mice; Muscle, Skeletal - cytology; Muscle, Skeletal - embryology; Muscle, Skeletal - metabolism; Regeneration; Spectrin - metabolism; Time Factors

The aim of this study was to optimize human muscle formation in vivo from implanted human muscle precursor cells. We transplanted donor muscle precursor cells (MPCs) prepared from postnatal or fetal human muscle into immunodeficient host mice and showed that irradiation of host muscle significantly...