Gut membrane proteins as candidate antigens for immunization of mice against the tick Amblyomma sculptum
•Amblyomma sculptum is one the most important tick species in south America.•Few works have focused on the search for anti-A. sculptum vaccines.•Concealed gut proteins may be promissing vaccine antigens against A. sculptum.•A chimeric protein was constructed with promising efficacy against A. sculpt...
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Published in | Vaccine Vol. 42; no. 21; p. 126141 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
30.08.2024
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Abstract | •Amblyomma sculptum is one the most important tick species in south America.•Few works have focused on the search for anti-A. sculptum vaccines.•Concealed gut proteins may be promissing vaccine antigens against A. sculptum.•A chimeric protein was constructed with promising efficacy against A. sculptum.•Vaccine induced a reduction in female fertility and nymph mortality.
Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF). Tick gut proteins play an essential role in blood feeding, digestion, and protection of gut epithelium. Therefore, many of these were investigated as potential vaccine targets for tick-control strategies. The present study aimed to select transcripts corresponding to putative immunogenic proteins in the A. sculptum gut epithelial membrane, produce recombinant proteins and evaluate them as antigens against A. sculptum infestations. Three gut proteins − AsMucin, AsAPP, and AsLAMP − and a chimeric protein (rAsChimera) based on 22 peptides containing putative B cell epitopes from seven different gut proteins were evaluated as anti-A. sculptum antigens. Mice immunizations revealed that all recombinant targets elicited humoral response with significantly increased IgG levels compared to controls. For rAsChimera, IgG levels remained significantly higher than controls up to 75 days after the end of the immunization. Challenge trials revealed that vaccination with the chimeric protein was the most effective against A. sculptum, inducing 100 % nymph mortality and reaching 80.8 % efficacy against females. The other three proteins did not induce relevant protection, as AsAPP had only 26.6 % efficacy, whereas AsMucin and AsLAMP induced no protection. These data indicate that targeting gut protein immunogenic regions may be an effective strategy for a vaccine formulation againstA. sculptum. |
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AbstractList | Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF). Tick gut proteins play an essential role in blood feeding, digestion, and protection of gut epithelium. Therefore, many of these were investigated as potential vaccine targets for tick-control strategies. The present study aimed to select transcripts corresponding to putative immunogenic proteins in the A. sculptum gut epithelial membrane, produce recombinant proteins and evaluate them as antigens against A. sculptum infestations. Three gut proteins - AsMucin, AsAPP, and AsLAMP - and a chimeric protein (rAsChimera) based on 22 peptides containing putative B cell epitopes from seven different gut proteins were evaluated as anti-A. sculptum antigens. Mice immunizations revealed that all recombinant targets elicited humoral response with significantly increased IgG levels compared to controls. For rAsChimera, IgG levels remained significantly higher than controls up to 75 days after the end of the immunization. Challenge trials revealed that vaccination with the chimeric protein was the most effective against A. sculptum, inducing 100 % nymph mortality and reaching 80.8 % efficacy against females. The other three proteins did not induce relevant protection, as AsAPP had only 26.6 % efficacy, whereas AsMucin and AsLAMP induced no protection. These data indicate that targeting gut protein immunogenic regions may be an effective strategy for a vaccine formulation againstA. sculptum.Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF). Tick gut proteins play an essential role in blood feeding, digestion, and protection of gut epithelium. Therefore, many of these were investigated as potential vaccine targets for tick-control strategies. The present study aimed to select transcripts corresponding to putative immunogenic proteins in the A. sculptum gut epithelial membrane, produce recombinant proteins and evaluate them as antigens against A. sculptum infestations. Three gut proteins - AsMucin, AsAPP, and AsLAMP - and a chimeric protein (rAsChimera) based on 22 peptides containing putative B cell epitopes from seven different gut proteins were evaluated as anti-A. sculptum antigens. Mice immunizations revealed that all recombinant targets elicited humoral response with significantly increased IgG levels compared to controls. For rAsChimera, IgG levels remained significantly higher than controls up to 75 days after the end of the immunization. Challenge trials revealed that vaccination with the chimeric protein was the most effective against A. sculptum, inducing 100 % nymph mortality and reaching 80.8 % efficacy against females. The other three proteins did not induce relevant protection, as AsAPP had only 26.6 % efficacy, whereas AsMucin and AsLAMP induced no protection. These data indicate that targeting gut protein immunogenic regions may be an effective strategy for a vaccine formulation againstA. sculptum. Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF). Tick gut proteins play an essential role in blood feeding, digestion, and protection of gut epithelium. Therefore, many of these were investigated as potential vaccine targets for tick-control strategies. The present study aimed to select transcripts corresponding to putative immunogenic proteins in the A. sculptum gut epithelial membrane, produce recombinant proteins and evaluate them as antigens against A. sculptum infestations. Three gut proteins − AsMucin, AsAPP, and AsLAMP − and a chimeric protein (rAsChimera) based on 22 peptides containing putative B cell epitopes from seven different gut proteins were evaluated as anti-A. sculptum antigens. Mice immunizations revealed that all recombinant targets elicited humoral response with significantly increased IgG levels compared to controls. For rAsChimera, IgG levels remained significantly higher than controls up to 75 days after the end of the immunization. Challenge trials revealed that vaccination with the chimeric protein was the most effective against A. sculptum, inducing 100 % nymph mortality and reaching 80.8 % efficacy against females. The other three proteins did not induce relevant protection, as AsAPP had only 26.6 % efficacy, whereas AsMucin and AsLAMP induced no protection. These data indicate that targeting gut protein immunogenic regions may be an effective strategy for a vaccine formulation againstA. sculptum. •Amblyomma sculptum is one the most important tick species in south America.•Few works have focused on the search for anti-A. sculptum vaccines.•Concealed gut proteins may be promissing vaccine antigens against A. sculptum.•A chimeric protein was constructed with promising efficacy against A. sculptum.•Vaccine induced a reduction in female fertility and nymph mortality. Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF). Tick gut proteins play an essential role in blood feeding, digestion, and protection of gut epithelium. Therefore, many of these were investigated as potential vaccine targets for tick-control strategies. The present study aimed to select transcripts corresponding to putative immunogenic proteins in the A. sculptum gut epithelial membrane, produce recombinant proteins and evaluate them as antigens against A. sculptum infestations. Three gut proteins − AsMucin, AsAPP, and AsLAMP − and a chimeric protein (rAsChimera) based on 22 peptides containing putative B cell epitopes from seven different gut proteins were evaluated as anti-A. sculptum antigens. Mice immunizations revealed that all recombinant targets elicited humoral response with significantly increased IgG levels compared to controls. For rAsChimera, IgG levels remained significantly higher than controls up to 75 days after the end of the immunization. Challenge trials revealed that vaccination with the chimeric protein was the most effective against A. sculptum, inducing 100 % nymph mortality and reaching 80.8 % efficacy against females. The other three proteins did not induce relevant protection, as AsAPP had only 26.6 % efficacy, whereas AsMucin and AsLAMP induced no protection. These data indicate that targeting gut protein immunogenic regions may be an effective strategy for a vaccine formulation againstA. sculptum. Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF). Tick gut proteins play an essential role in blood feeding, digestion, and protection of gut epithelium. Therefore, many of these were investigated as potential vaccine targets for tick-control strategies. The present study aimed to select transcripts corresponding to putative immunogenic proteins in the A. sculptum gut epithelial membrane, produce recombinant proteins and evaluate them as antigens against A. sculptum infestations. Three gut proteins - AsMucin, AsAPP, and AsLAMP - and a chimeric protein (rAsChimera) based on 22 peptides containing putative B cell epitopes from seven different gut proteins were evaluated as anti-A. sculptum antigens. Mice immunizations revealed that all recombinant targets elicited humoral response with significantly increased IgG levels compared to controls. For rAsChimera, IgG levels remained significantly higher than controls up to 75 days after the end of the immunization. Challenge trials revealed that vaccination with the chimeric protein was the most effective against A. sculptum, inducing 100 % nymph mortality and reaching 80.8 % efficacy against females. The other three proteins did not induce relevant protection, as AsAPP had only 26.6 % efficacy, whereas AsMucin and AsLAMP induced no protection. These data indicate that targeting gut protein immunogenic regions may be an effective strategy for a vaccine formulation againstA. sculptum. |
ArticleNumber | 126141 |
Author | Koerich, Leonardo B. Pessoa, Grasielle C.D. Valenzuela, Jesus G. Bartholomeu, Daniella C. Ribeiro, Izabela C.T. Sant'Anna, Mauricio R.V. Giunchetti, Rodolfo C. Oliveira, Fabiano Araujo, Ricardo N. Gontijo, Nelder F. Pereira, Marcos H. Fujiwara, Ricardo T. Costa, Gabriel C.A. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39033080$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S0304-4017(96)01082-5 10.3390/pathogens12111304 10.1007/s000180050430 10.1016/j.ttbdis.2015.12.012 10.1111/j.1365-3024.2006.00902.x 10.20506/rst.13.4.816 10.3390/pathogens12030374 10.1016/j.vetpar.2023.109932 10.1128/mbio.02319-22 10.1007/s10493-006-9027-0 10.1093/bioinformatics/bti299 10.1590/S1415-475738420150040 10.5772/intechopen.69273 10.1016/j.bej.2010.07.008 10.1016/j.vaccine.2012.03.020 10.1038/s41598-019-42899-z 10.1016/0264-410X(95)00119-L 10.3389/fcimb.2013.00027 10.1017/S1466252307001193 10.1007/s10493-010-9389-1 10.3389/fphys.2018.01696 10.1016/j.ttbdis.2019.101328 10.3390/ani13122031 10.1016/0169-4758(88)90084-1 10.3389/fimmu.2020.611104 10.1007/BF01200452 10.3390/pathogens12091071 10.1016/j.crbiot.2021.01.001 10.1186/s13071-024-06136-5 10.1111/j.1365-3024.1990.tb00943.x 10.1186/s13071-021-05122-5 10.1016/S0264-410X(96)00192-2 10.1016/j.ttbdis.2013.11.004 10.1186/1472-6750-1-3 10.1093/bioinformatics/bty036 10.1016/0003-2697(76)90527-3 10.1111/tbed.13455 10.1038/emboj.2013.79 10.1371/journal.pone.0000405 10.1186/s13071-023-05701-8 10.1111/imb.12068 10.4049/jimmunol.143.4.1346 10.3390/pathogens12020231 10.1111/1744-7917.13317 10.1603/0022-2585-37.4.601 |
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References | Rodríguez-Mallon (b0225) 2023; 12 Sonnhammer ELL, von Heijne G, Krogh A. A Hidden Markov Model for Predicting Transmembrane Helices in Protein Sequences 1998. Jackson, Opdebeeck (b0140) 1990; 12 Nassar, Martins, De Assis, Esteves, Sá-Nunes, Labruna (b0090) 2023; 16 Guglielmone, Beati, Barros-Battesti, Labruna, Nava, Venzal (b0010) 2006; 40 Kunz SE, Kemp DH. Insecticides and acaricides : resistance and environmental impact 1994;13:1249. Lew-Tabor, Rodriguez (b0165) 2016; 7 Berlese, 1888 (Ixodida: Ixodidae). Ticks and Tick-Borne Diseases 2014;5:252–76. https://doi.org/10.1016/j.ttbdis.2013.11.004. Souza Freitas, Zapata, Fernandes (b0030) 2011; 53 Gíslason, Nielsen, Almagro Armenteros, Johansen (b0175) 2021; 3 n. sp. Canales, Moreno-Cid, Almazán, Villar, De La Fuente (b0190) 2010; 52 Rodriguez M, Massard CL, Ramo NF, Labarta V. Effect of vaccination with a recombinant Bm86 antigen preparation on natural infestations of Willadsen, Kemp (b0045) 1988; 4 de la Fuente, Almazán, Canales, Pérez De La Lastra, Kocan, Willadsen (b0060) 2007; 8 Zhong, Jasinskas, Barbour (b0245) 2007; 2 Maitre, Wu-Chuang, Aželytė, Palinauskas, Mateos-Hernández, Obregon (b0235) 2022; 15 n. sp. and de la Fuente, Canales, Kocan (b0185) 2006; 28 . Steentoft, Vakhrushev, Joshi, Kong, Vester-Christensen, Schjoldager (b0130) 2013; 32 Valle, Montero, Machado, Joglar (b0150) 2001; 1 Gupta, Brunak (b0125) 2002; 7 Machado-Ferreira, Vizzoni, Piesman, Gazeta, Soares (b0240) 2015; 38 da Silva Vaz Jr, Lu, Pinto, Diedrich, Yates, Mulenga (b0155) 2024; 17 Canales, Enríquez, Ramos, Cabrera, Dandie, Soto (b0055) 1997; 15 Slastnikova, Ulasov, Rosenkranz, Sobolev (b0180) 2018 Ribas-Aparicio RM, Castelán J, Alicia J, Monterrubio G, Gerardo A. The Impact of Bioinformatics on Vaccine Design and Development, 2017. https://doi.org/10.5772/intechopen.69273. Wong, Opdebeeck (b0220) 1989; 66 Koch, 1844, and Kemp, Pearson, Gough, Willadsen (b0145) 1989; 7 Parizi, Githaka, Logullo, Zhou, Onuma, Termignoni (b0040) 2023; 13 Bouchard KR, Wikel SK. Care, Maintenance, and Experimental Infestation of Ticks in the Laboratory Setting. Biology of Disease Vectors, Marquardt, WC; 2005, p. 705–12. (Fabricius, 1787) with the description of three new species Fankhauser, Mäser (b0115) 2005; 21 Costa, Silva, Manzato, Torquato, Gonzalez, Parizi (b0230) 2023; 318 Reis-Cunha JL, Coqueiro-Dos-Santos A, Pimenta-Carvalho SA, Marques LP, Rodrigues-Luiz GF, Baptista RP, et al. Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families. mBio 2022;13:e0231922. Rodríguez-Valle, Taoufik, Valdés, Montero, Hassan, Hassan (b0080) 2012; 30 Kõressaar, Lepamets, Kaplinski, Raime, Andreson, Remm (b0135) 2018; 34 n. sp., and reinstatement of in grazing dairy and beef pure and cross-bred cattle in Brazil 1995;13:1804–8. https://doi.org/10.1016/0264-410x(95)00119-l. Rodríguez-Mallon, Encinosa Guzmán, Bello Soto, Rosales Perdomo, Montero Espinosa, Vargas (b0250) 2020; 67 Bishop, Stutzer, Maritz-Olivier (b0070) 2023; 12 Sahibi, Rhalem, Barriga (b0215) 1997; 68 Costa, Ribeiro, Melo-Junior, Gontijo, Sant’Anna, Pereira (b0085) 2021; 11 Knorr, Anguita, Cortazar, Hajdusek, Kopáček, Trentelman (b0210) 2018; 9 Szabó, Pinter, Labruna (b0020) 2013; 3 Bradford (b0100) 1976; 72 Cardoso, Carvalho, Dias, Santos, Tavares, Neves (b0025) 2023; 12 Arcà, Struchiner, Pham, Sferra, Lombardo, Pombi (b0160) 2014; 23 Willadsen, Riding, McKenna, Kemp, Tellam, Nielsen (b0065) 1989; 143 Antunes, Domingos (b0050) 2023; 12 Nava S, Beati L, Labruna MB, Cáceres AG, Mangold AJ, Guglielmone AA. Reassessment of the taxonomic status of Jittapalapong, Stich, Gordon, Wittum, Barriga (b0205) 2000; 37 Sant’Anna, Pereira-Filho, Mendes-Sousa, Silva, Gontijo, Pereira (b0195) 2024 Araujo, Silva, Mendes-Sousa, Paim, Costa, Dias (b0105) 2019; 9 Szabó, Martins, Barbieri, Costa, Soares, Tolesano-Pascoli (b0015) 2020; 11 Wang, Nuttall (b0200) 1999; 56 Zhong (10.1016/j.vaccine.2024.07.042_b0245) 2007; 2 Gíslason (10.1016/j.vaccine.2024.07.042_b0175) 2021; 3 Knorr (10.1016/j.vaccine.2024.07.042_b0210) 2018; 9 Arcà (10.1016/j.vaccine.2024.07.042_b0160) 2014; 23 Nassar (10.1016/j.vaccine.2024.07.042_b0090) 2023; 16 Willadsen (10.1016/j.vaccine.2024.07.042_b0065) 1989; 143 Kemp (10.1016/j.vaccine.2024.07.042_b0145) 1989; 7 Slastnikova (10.1016/j.vaccine.2024.07.042_b0180) 2018 Steentoft (10.1016/j.vaccine.2024.07.042_b0130) 2013; 32 Gupta (10.1016/j.vaccine.2024.07.042_b0125) 2002; 7 Valle (10.1016/j.vaccine.2024.07.042_b0150) 2001; 1 Bishop (10.1016/j.vaccine.2024.07.042_b0070) 2023; 12 Canales (10.1016/j.vaccine.2024.07.042_b0190) 2010; 52 10.1016/j.vaccine.2024.07.042_b0170 Costa (10.1016/j.vaccine.2024.07.042_b0230) 2023; 318 10.1016/j.vaccine.2024.07.042_b0095 Willadsen (10.1016/j.vaccine.2024.07.042_b0045) 1988; 4 10.1016/j.vaccine.2024.07.042_b0005 Machado-Ferreira (10.1016/j.vaccine.2024.07.042_b0240) 2015; 38 Kõressaar (10.1016/j.vaccine.2024.07.042_b0135) 2018; 34 Maitre (10.1016/j.vaccine.2024.07.042_b0235) 2022; 15 Szabó (10.1016/j.vaccine.2024.07.042_b0020) 2013; 3 Guglielmone (10.1016/j.vaccine.2024.07.042_b0010) 2006; 40 de la Fuente (10.1016/j.vaccine.2024.07.042_b0060) 2007; 8 Cardoso (10.1016/j.vaccine.2024.07.042_b0025) 2023; 12 Rodríguez-Mallon (10.1016/j.vaccine.2024.07.042_b0225) 2023; 12 Araujo (10.1016/j.vaccine.2024.07.042_b0105) 2019; 9 10.1016/j.vaccine.2024.07.042_b0120 10.1016/j.vaccine.2024.07.042_b0035 da Silva Vaz Jr (10.1016/j.vaccine.2024.07.042_b0155) 2024; 17 Sant’Anna (10.1016/j.vaccine.2024.07.042_b0195) 2024 Parizi (10.1016/j.vaccine.2024.07.042_b0040) 2023; 13 Szabó (10.1016/j.vaccine.2024.07.042_b0015) 2020; 11 Fankhauser (10.1016/j.vaccine.2024.07.042_b0115) 2005; 21 Rodríguez-Mallon (10.1016/j.vaccine.2024.07.042_b0250) 2020; 67 Wang (10.1016/j.vaccine.2024.07.042_b0200) 1999; 56 de la Fuente (10.1016/j.vaccine.2024.07.042_b0185) 2006; 28 Wong (10.1016/j.vaccine.2024.07.042_b0220) 1989; 66 Bradford (10.1016/j.vaccine.2024.07.042_b0100) 1976; 72 Sahibi (10.1016/j.vaccine.2024.07.042_b0215) 1997; 68 Lew-Tabor (10.1016/j.vaccine.2024.07.042_b0165) 2016; 7 10.1016/j.vaccine.2024.07.042_b0075 Rodríguez-Valle (10.1016/j.vaccine.2024.07.042_b0080) 2012; 30 10.1016/j.vaccine.2024.07.042_b0110 Jackson (10.1016/j.vaccine.2024.07.042_b0140) 1990; 12 Costa (10.1016/j.vaccine.2024.07.042_b0085) 2021; 11 Jittapalapong (10.1016/j.vaccine.2024.07.042_b0205) 2000; 37 Souza Freitas (10.1016/j.vaccine.2024.07.042_b0030) 2011; 53 Antunes (10.1016/j.vaccine.2024.07.042_b0050) 2023; 12 Canales (10.1016/j.vaccine.2024.07.042_b0055) 1997; 15 |
References_xml | – volume: 2 start-page: e405 year: 2007 ident: b0245 article-title: Antibiotic Treatment of the Tick Vector publication-title: PLoS One contributor: fullname: Barbour – volume: 12 start-page: 231 year: 2023 ident: b0225 article-title: The Bm86 Discovery: a revolution in the development of anti-tick vaccines publication-title: Pathogens contributor: fullname: Rodríguez-Mallon – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: b0100 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem contributor: fullname: Bradford – volume: 15 start-page: 4 year: 2022 ident: b0235 article-title: Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines publication-title: Parasit Vectors contributor: fullname: Obregon – volume: 12 start-page: 1304 year: 2023 ident: b0025 article-title: Susceptibility of publication-title: Pathogens contributor: fullname: Neves – volume: 15 start-page: 414 year: 1997 end-page: 422 ident: b0055 article-title: Large-scale production in publication-title: Vaccine contributor: fullname: Soto – start-page: 9 year: 2018 ident: b0180 article-title: Targeted Intracellular Delivery of Antibodies: The State of the Art publication-title: Front Pharmacol contributor: fullname: Sobolev – volume: 12 start-page: 1071 year: 2023 ident: b0070 article-title: More than Three Decades of Bm86: What We Know and Where to Go publication-title: Pathogens contributor: fullname: Maritz-Olivier – volume: 34 start-page: 1937 year: 2018 end-page: 1938 ident: b0135 article-title: Primer3_masker: integrating masking of template sequence with primer design software publication-title: Bioinformatics contributor: fullname: Remm – volume: 21 start-page: 1846 year: 2005 end-page: 1852 ident: b0115 article-title: Identification of GPI anchor attachment signals by a Kohonen self-organizing map publication-title: Bioinformatics contributor: fullname: Mäser – volume: 3 year: 2013 ident: b0020 article-title: Ecology, biology and distribution of spotted-fever tick vectors in Brazil publication-title: Front Cell Infect Microbiol contributor: fullname: Labruna – volume: 8 start-page: 23 year: 2007 end-page: 28 ident: b0060 article-title: A ten-year review of commercial vaccine performance for control of tick infestations on cattle publication-title: Anim Health Res Rev contributor: fullname: Willadsen – volume: 66 start-page: 149 year: 1989 end-page: 155 ident: b0220 article-title: Protective efficacy of antigens solubilized from gut membranes of the cattle tick publication-title: Immunology contributor: fullname: Opdebeeck – volume: 9 start-page: 1696 year: 2018 ident: b0210 article-title: Preliminary evaluation of tick protein extracts and recombinant ferritin 2 as anti-tick vaccines targeting publication-title: Front Physiol contributor: fullname: Trentelman – volume: 68 start-page: 359 year: 1997 end-page: 366 ident: b0215 article-title: Comparative immunizing power of infections, salivary extracts, and intestinal extracts of publication-title: Vet Parasitol contributor: fullname: Barriga – volume: 17 start-page: 36 year: 2024 ident: b0155 article-title: Changes in saliva protein profile throughout publication-title: Parasites Vectors contributor: fullname: Mulenga – volume: 56 start-page: 286 year: 1999 end-page: 295 ident: b0200 article-title: Immunoglobulin-binding proteins in ticks: new target for vaccine development against a blood-feeding parasite: CMLS publication-title: Cell Mol Life Sci contributor: fullname: Nuttall – volume: 4 start-page: 196 year: 1988 end-page: 198 ident: b0045 article-title: Vaccination with ‘concealed’ antigens for tick control publication-title: Parasitol Today contributor: fullname: Kemp – volume: 3 start-page: 6 year: 2021 end-page: 13 ident: b0175 article-title: Prediction of GPI-anchored proteins with pointer neural networks publication-title: Current Res Biotechnol contributor: fullname: Johansen – volume: 53 start-page: 189 year: 2011 end-page: 202 ident: b0030 article-title: Monitoring of resistance or susceptibility of adults and larvae of Amblyomma cajennense (Acari: Ixodidae) to synthetic acaricides in Goiás publication-title: Brazil Exp Appl Acarol contributor: fullname: Fernandes – volume: 12 start-page: 374 year: 2023 ident: b0050 article-title: Tick vaccines and concealed versus exposed antigens publication-title: Pathogens contributor: fullname: Domingos – volume: 7 start-page: 573 year: 2016 end-page: 585 ident: b0165 article-title: A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases publication-title: Ticks Tick-borne Dis contributor: fullname: Rodriguez – volume: 37 start-page: 601 year: 2000 end-page: 611 ident: b0205 article-title: Performance of Female Rhipicephalus sanguineus (Acari: Ixodidae) fed on dogs exposed to multiple infestations or immunization with tick salivary gland or midgut tissues publication-title: Me contributor: fullname: Barriga – volume: 16 start-page: 96 year: 2023 ident: b0090 article-title: The survival of publication-title: Parasites Vectors contributor: fullname: Labruna – volume: 318 year: 2023 ident: b0230 article-title: A multiepitope chimeric antigen from publication-title: Vet Parasitol contributor: fullname: Parizi – volume: 11 year: 2020 ident: b0015 article-title: Ticks biting humans in the brazilian savannah: attachment sites and exposure risk in relation to species, life stage and season publication-title: Ticks Tick-borne Dis contributor: fullname: Tolesano-Pascoli – volume: 7 start-page: 310 year: 2002 end-page: 322 ident: b0125 article-title: Prediction of glycosylation across the human proteome and the correlation to protein function publication-title: Pac Symp Biocomput contributor: fullname: Brunak – volume: 11 year: 2021 ident: b0085 article-title: salivary protease inhibitors as potential anti-tick vaccines publication-title: Front Immunol contributor: fullname: Pereira – volume: 23 start-page: 122 year: 2014 end-page: 131 ident: b0160 article-title: Positive selection drives accelerated evolution of mosquito salivary genes associated with blood-feeding publication-title: Insect Mol Biol contributor: fullname: Pombi – volume: 40 start-page: 83 year: 2006 end-page: 100 ident: b0010 article-title: Ticks (Ixodidae) on humans in South America publication-title: Exp Appl Acarol contributor: fullname: Venzal – volume: 67 start-page: 175 year: 2020 end-page: 177 ident: b0250 article-title: A chemical conjugate of the tick P0 peptide is efficacious against publication-title: Transbound Emerg Dis contributor: fullname: Vargas – volume: 52 start-page: 79 year: 2010 end-page: 90 ident: b0190 article-title: Bioprocess design and economics of recombinant BM86/BM95 antigen production for anti-tick vaccines publication-title: Biochem Eng J contributor: fullname: De La Fuente – volume: 38 start-page: 477 year: 2015 end-page: 483 ident: b0240 article-title: Bacteria associated with publication-title: Genet Mol Biol contributor: fullname: Soares – volume: 143 start-page: 1346 year: 1989 end-page: 1351 ident: b0065 article-title: Immunologic control of a parasitic arthropod. Identification of a protective antigen from publication-title: J Immunol contributor: fullname: Nielsen – volume: 32 start-page: 1478 year: 2013 end-page: 1488 ident: b0130 article-title: Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology publication-title: EMBO J contributor: fullname: Schjoldager – volume: 12 start-page: 141 year: 1990 end-page: 151 ident: b0140 article-title: Humoral immune responses of Hereford cattle vaccinated with midgut antigens of the cattle tick, publication-title: Parasite Immunology contributor: fullname: Opdebeeck – volume: 9 start-page: 6764 year: 2019 ident: b0105 article-title: RNA-seq analysis of the salivary glands and midgut of the Argasid tick publication-title: Sci Rep contributor: fullname: Dias – volume: 30 start-page: 3453 year: 2012 end-page: 3458 ident: b0080 article-title: Efficacy of Rhipicephalus (Boophilus) microplus Bm86 against Hyalomma dromedarii and Amblyomma cajennense tick infestations in camels and cattle publication-title: Vaccine contributor: fullname: Hassan – volume: 1 year: 2001 ident: b0150 article-title: The evaluation of yeast derivatives as adjuvants for the immune response to the Bm86 antigen in cattle publication-title: BMC Biotech contributor: fullname: Joglar – volume: 28 start-page: 687 year: 2006 end-page: 688 ident: b0185 article-title: The importance of protein glycosylation in development of novel tick vaccine strategies publication-title: Parasite Immunol contributor: fullname: Kocan – volume: 7 start-page: 43 year: 1989 end-page: 58 ident: b0145 article-title: Vaccination against publication-title: Exp Appl Acarol contributor: fullname: Willadsen – year: 2024 ident: b0195 article-title: Inhibition of vertebrate complement system by hematophagous arthropods: inhibitory molecules, mechanisms, physiological roles, and applications publication-title: Insect Science contributor: fullname: Pereira – volume: 13 start-page: 2031 year: 2023 ident: b0040 article-title: Universal tick vaccines: candidates and remaining challenges publication-title: Animals contributor: fullname: Termignoni – volume: 68 start-page: 359 year: 1997 ident: 10.1016/j.vaccine.2024.07.042_b0215 article-title: Comparative immunizing power of infections, salivary extracts, and intestinal extracts of Hyalomma marginatum marginatum in cattle publication-title: Vet Parasitol doi: 10.1016/S0304-4017(96)01082-5 contributor: fullname: Sahibi – volume: 7 start-page: 310 year: 2002 ident: 10.1016/j.vaccine.2024.07.042_b0125 article-title: Prediction of glycosylation across the human proteome and the correlation to protein function publication-title: Pac Symp Biocomput contributor: fullname: Gupta – volume: 12 start-page: 1304 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0025 article-title: Susceptibility of Amblyomma sculptum, Vector of Rickettsia rickettsii, Ticks from a National Park and an Experimental Farm to Different Synthetic Acaricides publication-title: Pathogens doi: 10.3390/pathogens12111304 contributor: fullname: Cardoso – volume: 56 start-page: 286 year: 1999 ident: 10.1016/j.vaccine.2024.07.042_b0200 article-title: Immunoglobulin-binding proteins in ticks: new target for vaccine development against a blood-feeding parasite: CMLS publication-title: Cell Mol Life Sci doi: 10.1007/s000180050430 contributor: fullname: Wang – volume: 7 start-page: 573 year: 2016 ident: 10.1016/j.vaccine.2024.07.042_b0165 article-title: A review of reverse vaccinology approaches for the development of vaccines against ticks and tick borne diseases publication-title: Ticks Tick-borne Dis doi: 10.1016/j.ttbdis.2015.12.012 contributor: fullname: Lew-Tabor – volume: 28 start-page: 687 year: 2006 ident: 10.1016/j.vaccine.2024.07.042_b0185 article-title: The importance of protein glycosylation in development of novel tick vaccine strategies publication-title: Parasite Immunol doi: 10.1111/j.1365-3024.2006.00902.x contributor: fullname: de la Fuente – ident: 10.1016/j.vaccine.2024.07.042_b0035 doi: 10.20506/rst.13.4.816 – volume: 12 start-page: 374 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0050 article-title: Tick vaccines and concealed versus exposed antigens publication-title: Pathogens doi: 10.3390/pathogens12030374 contributor: fullname: Antunes – volume: 318 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0230 article-title: A multiepitope chimeric antigen from Rhipicephalus microplus-secreted salivary proteins elicits anti-tick protective antibodies in rabbit publication-title: Vet Parasitol doi: 10.1016/j.vetpar.2023.109932 contributor: fullname: Costa – ident: 10.1016/j.vaccine.2024.07.042_b0110 doi: 10.1128/mbio.02319-22 – volume: 40 start-page: 83 year: 2006 ident: 10.1016/j.vaccine.2024.07.042_b0010 article-title: Ticks (Ixodidae) on humans in South America publication-title: Exp Appl Acarol doi: 10.1007/s10493-006-9027-0 contributor: fullname: Guglielmone – volume: 21 start-page: 1846 year: 2005 ident: 10.1016/j.vaccine.2024.07.042_b0115 article-title: Identification of GPI anchor attachment signals by a Kohonen self-organizing map publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti299 contributor: fullname: Fankhauser – volume: 38 start-page: 477 year: 2015 ident: 10.1016/j.vaccine.2024.07.042_b0240 article-title: Bacteria associated with Amblyomma cajennense tick eggs publication-title: Genet Mol Biol doi: 10.1590/S1415-475738420150040 contributor: fullname: Machado-Ferreira – ident: 10.1016/j.vaccine.2024.07.042_b0170 doi: 10.5772/intechopen.69273 – volume: 52 start-page: 79 year: 2010 ident: 10.1016/j.vaccine.2024.07.042_b0190 article-title: Bioprocess design and economics of recombinant BM86/BM95 antigen production for anti-tick vaccines publication-title: Biochem Eng J doi: 10.1016/j.bej.2010.07.008 contributor: fullname: Canales – volume: 30 start-page: 3453 year: 2012 ident: 10.1016/j.vaccine.2024.07.042_b0080 article-title: Efficacy of Rhipicephalus (Boophilus) microplus Bm86 against Hyalomma dromedarii and Amblyomma cajennense tick infestations in camels and cattle publication-title: Vaccine doi: 10.1016/j.vaccine.2012.03.020 contributor: fullname: Rodríguez-Valle – volume: 9 start-page: 6764 year: 2019 ident: 10.1016/j.vaccine.2024.07.042_b0105 article-title: RNA-seq analysis of the salivary glands and midgut of the Argasid tick Ornithodoros rostratus publication-title: Sci Rep doi: 10.1038/s41598-019-42899-z contributor: fullname: Araujo – ident: 10.1016/j.vaccine.2024.07.042_b0075 doi: 10.1016/0264-410X(95)00119-L – volume: 3 year: 2013 ident: 10.1016/j.vaccine.2024.07.042_b0020 article-title: Ecology, biology and distribution of spotted-fever tick vectors in Brazil publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2013.00027 contributor: fullname: Szabó – volume: 8 start-page: 23 year: 2007 ident: 10.1016/j.vaccine.2024.07.042_b0060 article-title: A ten-year review of commercial vaccine performance for control of tick infestations on cattle publication-title: Anim Health Res Rev doi: 10.1017/S1466252307001193 contributor: fullname: de la Fuente – volume: 53 start-page: 189 year: 2011 ident: 10.1016/j.vaccine.2024.07.042_b0030 article-title: Monitoring of resistance or susceptibility of adults and larvae of Amblyomma cajennense (Acari: Ixodidae) to synthetic acaricides in Goiás publication-title: Brazil Exp Appl Acarol doi: 10.1007/s10493-010-9389-1 contributor: fullname: Souza Freitas – volume: 9 start-page: 1696 year: 2018 ident: 10.1016/j.vaccine.2024.07.042_b0210 article-title: Preliminary evaluation of tick protein extracts and recombinant ferritin 2 as anti-tick vaccines targeting Ixodes ricinus in cattle publication-title: Front Physiol doi: 10.3389/fphys.2018.01696 contributor: fullname: Knorr – volume: 11 year: 2020 ident: 10.1016/j.vaccine.2024.07.042_b0015 article-title: Ticks biting humans in the brazilian savannah: attachment sites and exposure risk in relation to species, life stage and season publication-title: Ticks Tick-borne Dis doi: 10.1016/j.ttbdis.2019.101328 contributor: fullname: Szabó – volume: 13 start-page: 2031 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0040 article-title: Universal tick vaccines: candidates and remaining challenges publication-title: Animals doi: 10.3390/ani13122031 contributor: fullname: Parizi – ident: 10.1016/j.vaccine.2024.07.042_b0120 – volume: 4 start-page: 196 year: 1988 ident: 10.1016/j.vaccine.2024.07.042_b0045 article-title: Vaccination with ‘concealed’ antigens for tick control publication-title: Parasitol Today doi: 10.1016/0169-4758(88)90084-1 contributor: fullname: Willadsen – start-page: 9 year: 2018 ident: 10.1016/j.vaccine.2024.07.042_b0180 article-title: Targeted Intracellular Delivery of Antibodies: The State of the Art publication-title: Front Pharmacol contributor: fullname: Slastnikova – volume: 11 year: 2021 ident: 10.1016/j.vaccine.2024.07.042_b0085 article-title: Amblyomma sculptum salivary protease inhibitors as potential anti-tick vaccines publication-title: Front Immunol doi: 10.3389/fimmu.2020.611104 contributor: fullname: Costa – volume: 7 start-page: 43 year: 1989 ident: 10.1016/j.vaccine.2024.07.042_b0145 article-title: Vaccination against Boophilus microplus: Localization of antigens on tick gut cells and their interaction with the host immune system publication-title: Exp Appl Acarol doi: 10.1007/BF01200452 contributor: fullname: Kemp – volume: 12 start-page: 1071 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0070 article-title: More than Three Decades of Bm86: What We Know and Where to Go publication-title: Pathogens doi: 10.3390/pathogens12091071 contributor: fullname: Bishop – volume: 3 start-page: 6 year: 2021 ident: 10.1016/j.vaccine.2024.07.042_b0175 article-title: Prediction of GPI-anchored proteins with pointer neural networks publication-title: Current Res Biotechnol doi: 10.1016/j.crbiot.2021.01.001 contributor: fullname: Gíslason – volume: 17 start-page: 36 year: 2024 ident: 10.1016/j.vaccine.2024.07.042_b0155 article-title: Changes in saliva protein profile throughout Rhipicephalus microplus blood feeding publication-title: Parasites Vectors doi: 10.1186/s13071-024-06136-5 contributor: fullname: da Silva Vaz Jr – volume: 12 start-page: 141 year: 1990 ident: 10.1016/j.vaccine.2024.07.042_b0140 article-title: Humoral immune responses of Hereford cattle vaccinated with midgut antigens of the cattle tick, Boophilus microplus publication-title: Parasite Immunology doi: 10.1111/j.1365-3024.1990.tb00943.x contributor: fullname: Jackson – volume: 15 start-page: 4 year: 2022 ident: 10.1016/j.vaccine.2024.07.042_b0235 article-title: Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines publication-title: Parasit Vectors doi: 10.1186/s13071-021-05122-5 contributor: fullname: Maitre – volume: 15 start-page: 414 year: 1997 ident: 10.1016/j.vaccine.2024.07.042_b0055 article-title: Large-scale production in Pichia pastoris of the recombinant vaccine GavacTM against cattle tick publication-title: Vaccine doi: 10.1016/S0264-410X(96)00192-2 contributor: fullname: Canales – ident: 10.1016/j.vaccine.2024.07.042_b0095 – ident: 10.1016/j.vaccine.2024.07.042_b0005 doi: 10.1016/j.ttbdis.2013.11.004 – volume: 66 start-page: 149 year: 1989 ident: 10.1016/j.vaccine.2024.07.042_b0220 article-title: Protective efficacy of antigens solubilized from gut membranes of the cattle tick publication-title: Boophilus microplus Immunology contributor: fullname: Wong – volume: 1 year: 2001 ident: 10.1016/j.vaccine.2024.07.042_b0150 article-title: The evaluation of yeast derivatives as adjuvants for the immune response to the Bm86 antigen in cattle publication-title: BMC Biotech doi: 10.1186/1472-6750-1-3 contributor: fullname: Valle – volume: 34 start-page: 1937 year: 2018 ident: 10.1016/j.vaccine.2024.07.042_b0135 article-title: Primer3_masker: integrating masking of template sequence with primer design software publication-title: Bioinformatics doi: 10.1093/bioinformatics/bty036 contributor: fullname: Kõressaar – volume: 72 start-page: 248 year: 1976 ident: 10.1016/j.vaccine.2024.07.042_b0100 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal Biochem doi: 10.1016/0003-2697(76)90527-3 contributor: fullname: Bradford – volume: 67 start-page: 175 year: 2020 ident: 10.1016/j.vaccine.2024.07.042_b0250 article-title: A chemical conjugate of the tick P0 peptide is efficacious against Amblyomma mixtum publication-title: Transbound Emerg Dis doi: 10.1111/tbed.13455 contributor: fullname: Rodríguez-Mallon – volume: 32 start-page: 1478 year: 2013 ident: 10.1016/j.vaccine.2024.07.042_b0130 article-title: Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology publication-title: EMBO J doi: 10.1038/emboj.2013.79 contributor: fullname: Steentoft – volume: 2 start-page: e405 year: 2007 ident: 10.1016/j.vaccine.2024.07.042_b0245 article-title: Antibiotic Treatment of the Tick Vector Amblyomma americanum Reduced Reproductive Fitness publication-title: PLoS One doi: 10.1371/journal.pone.0000405 contributor: fullname: Zhong – volume: 16 start-page: 96 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0090 article-title: The survival of Amblyomma sculptum ticks upon blood-feeding depends on the expression of an inhibitor of apoptosis protein publication-title: Parasites Vectors doi: 10.1186/s13071-023-05701-8 contributor: fullname: Nassar – volume: 23 start-page: 122 year: 2014 ident: 10.1016/j.vaccine.2024.07.042_b0160 article-title: Positive selection drives accelerated evolution of mosquito salivary genes associated with blood-feeding publication-title: Insect Mol Biol doi: 10.1111/imb.12068 contributor: fullname: Arcà – volume: 143 start-page: 1346 year: 1989 ident: 10.1016/j.vaccine.2024.07.042_b0065 article-title: Immunologic control of a parasitic arthropod. Identification of a protective antigen from Boophilus microplus publication-title: J Immunol doi: 10.4049/jimmunol.143.4.1346 contributor: fullname: Willadsen – volume: 12 start-page: 231 year: 2023 ident: 10.1016/j.vaccine.2024.07.042_b0225 article-title: The Bm86 Discovery: a revolution in the development of anti-tick vaccines publication-title: Pathogens doi: 10.3390/pathogens12020231 contributor: fullname: Rodríguez-Mallon – year: 2024 ident: 10.1016/j.vaccine.2024.07.042_b0195 article-title: Inhibition of vertebrate complement system by hematophagous arthropods: inhibitory molecules, mechanisms, physiological roles, and applications publication-title: Insect Science doi: 10.1111/1744-7917.13317 contributor: fullname: Sant’Anna – volume: 37 start-page: 601 year: 2000 ident: 10.1016/j.vaccine.2024.07.042_b0205 article-title: Performance of Female Rhipicephalus sanguineus (Acari: Ixodidae) fed on dogs exposed to multiple infestations or immunization with tick salivary gland or midgut tissues publication-title: Me doi: 10.1603/0022-2585-37.4.601 contributor: fullname: Jittapalapong |
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Snippet | •Amblyomma sculptum is one the most important tick species in south America.•Few works have focused on the search for anti-A. sculptum vaccines.•Concealed gut... Amblyomma sculptum is widely distributed in Brazil and is the main vector of Rickettsia rickettsii, the causative agent of the Brazilian spotted fever (BSF).... |
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SubjectTerms | Amblyomma - immunology Amblyomma sculptum Amino acids Animals Anti-tick vaccine Antigens Antigens - immunology Brazil Cloning Concealed antigens Digestive system Digestive tract E coli Effectiveness Epithelium Epitopes Female Females Gut epithelium Hematophagy Immune response (humoral) Immunization Immunization - methods Immunogenicity Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Intestine Male Membrane proteins Membrane Proteins - genetics Membrane Proteins - immunology Membranes Mice Mice, Inbred BALB C Peptides Plasmids Proteins Recombinant Proteins - genetics Recombinant Proteins - immunology Rickettsia rickettsii - immunology Tick control Tick Infestations - immunology Tick Infestations - prevention & control Vaccines |
Title | Gut membrane proteins as candidate antigens for immunization of mice against the tick Amblyomma sculptum |
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