Influence of integrin-binding motif (RGD) on the attachment and internalization of avian adenovirus CELO in mammalian cells

Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a long-fiber HI loop was designed. Experiments in vitro revealed that the introduction of an RGD motif into the fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised th...

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Published inMolecular genetics, microbiology and virology Vol. 23; no. 2; pp. 89 - 93
Main Authors Zubkova, O. V., Logunov, D. Y., Karpov, A. P., Shmarov, M. M., Belousova, R. V., Naroditsky, B. S.
Format Journal Article
LanguageEnglish
Published Heidelberg Allerton Press, Inc 01.06.2008
Subjects
Adenovirus
Biomedical and Life Sciences
Experimental Articles
Life Sciences
Microbiology
Molecular Medicine
Virus Binding
PacI
Cell Integrins
Virus Internalization
Viral Particle
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Summary:Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a long-fiber HI loop was designed. Experiments in vitro revealed that the introduction of an RGD motif into the fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised the efficiency of the process of internalization of the virus both in CAR-positive and in CAR-negative cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0891-4168
1934-841X
DOI:10.3103/S0891416808020067